ArticleCirculation. Heart failure2013
Chronic heart failure does not attenuate the total activity of sympathetic outflow to skin during whole-body heating.
Article in Circulation. Heart failure, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Meta-analysis of heat-induced changes in cardiac function from over 400 laboratory-based heat exposure studies.Nature communications · 2025Pooled it
- Unveiling the Systemic Impact of Congestion in Heart Failure: A Narrative Review of Multisystem Pathophysiology and Clinical Implications.Journal of cardiovascular development and disease · 2025Review
- Experimental research in environmentally induced hyperthermic older persons: A systematic quantitative literature review mapping the available evidence.Temperature (Austin, Tex.) · 2024Article
- Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events.Temperature (Austin, Tex.) · 2024Review
- Core body temperature changes before sleep are associated with nocturnal heart rate variability.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Heat and the Heart.The Yale journal of biology and medicine · 2023Review
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Multiple Laser Doppler Flowmetry Probes Increase the Reproducibility of Skin Blood Flow Measurements.Frontiers in physiology · 2022Article
- Moderate whole body heating attenuates the exercise pressor reflex responses in older humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Hyperhidrosis: the neglected sign in heart failure patients.American journal of cardiovascular disease · 2021Review
- Individual Responses to Heat Stress: Implications for Hyperthermia and Physical Work Capacity.Frontiers in physiology · 2020Review
- Aging and Thermoregulatory Control: The Clinical Implications of Exercising under Heat Stress in Older Individuals.BioMed research international · 2018Review
- Volume loading augments cutaneous vasodilatation and cardiac output of heat stressed older adults.The Journal of physiology · 2017Article
- Measuring and quantifying skin sympathetic nervous system activity in humans.Journal of neurophysiology · 2017Review
- Muscle sympathetic nerve activity response to heat stress is attenuated in chronic heart failure patients.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Effects of postural change from supine to head-up tilt on the skin sympathetic nerve activity component synchronised with the cardiac cycle in warmed men.The Journal of physiology · 2017Article
- Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Altered thermoregulatory responses in heart failure patients exercising in the heat.Physiological reports · 2016Article
- Sympathetic regulation during thermal stress in human aging and disease.Autonomic neuroscience : basic & clinical · 2016Review
- Sympathetic activity during passive heat stress in healthy aged humans.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies show that the rise in skin blood flow and cutaneous vascular conductance during heat stress is substantially attenuated in chronic heart failure (CHF) patients. The mechanisms responsible for this finding are not clear. In particular, little is known regarding the responses of skin sympathetic nerve activity (SSNA) that control the skin blood flow during heat stress in CHF patients. We examined the effects of a modest heat stress to test the hypothesis that SSNA responses could be attenuated in CHF. METHODS AND
resultsWe assessed SSNA (microneurography) from the peroneal nerve and skin blood flow (forearm laser Doppler) in 9 patients with stable class II-III CHF and in matched healthy subjects during passive whole-body heating with a water-perfused suit. Whole-body heating induced similar increases in internal temperature (≈0.6 °C) in both groups. Whole-body heat stress evoked similar SSNA activation in CHF patients (Δ891±110 U/min) and the control subjects (Δ787±84 U/min; P=0.66), whereas the elevation in forearm cutaneous vascular conductance in patients with CHF was significantly lower than that in healthy control subjects (Δ131±29% vs. Δ623±131%; P=0.001).
conclusionsThe present data show that SSNA activation during a modest whole-body heat stress is not attenuated in CHF. Thus, the attenuated skin vasodilator response in CHF patients is not attributable to a reduction in total activity of sympathetic outflow to skin.
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