ArticleAmerican journal of obstetrics and gynecology2013
Association of early-preterm birth with abnormal levels of routinely collected first- and second-trimester biomarkers.
Article in American journal of obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review.PloS one · 2022Pooled it
- Steroid hormones in early pregnancy and adverse birth outcomes: a Chinese birth cohort.Frontiers in endocrinology · 2026Article
- The association and diagnostic value of maternal serum placental biomarkers for fetal hypospadias and cryptorchidism.Translational pediatrics · 2025Article
- Prediction of preterm birth in multiparous women using logistic regression and machine learning approaches.Scientific reports · 2024Article
- Placental transcriptomic signatures of spontaneous preterm birth.American journal of obstetrics and gynecology · 2023Article
- Clinical risk models for preterm birth less than 28 weeks and less than 32 weeks of gestation using a large retrospective cohort.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- A toolkit for the application of placental-fetal molecular biomarkers in epidemiologic studies of the fetal origins of chronic disease.Current epidemiology reports · 2021Article
- Prediction of preterm birth in nulliparous women using logistic regression and machine learning.PloS one · 2021Article
- Adverse Pregnancy Outcomes by Degree of Maternal Serum Analyte Elevation: A Retrospective Cohort Study.AJP reports · 2020Article
- Early pregnancy prediction of gestational diabetes mellitus risk using prenatal screening biomarkers in nulliparous women.Diabetes research and clinical practice · 2020Article
- Comparison of Genome-Wide and Gene-Specific DNA Methylation Profiling in First-Trimester Chorionic Villi From Pregnancies Conceived With Infertility Treatments.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Early first trimester peripheral blood cell microRNA predicts risk of preterm delivery in pregnant women: Proof of concept.PloS one · 2017Article
- Racial-ethnic differences in midtrimester maternal serum levels of angiogenic and antiangiogenic factors.American journal of obstetrics and gynecology · 2016Article
- Fetal sex differences in human chorionic gonadotropin fluctuate by maternal race, age, weight and by gestational age.Journal of developmental origins of health and disease · 2015Article
- Effects of race/ethnicity and BMI on the association between height and risk for spontaneous preterm birth.American journal of obstetrics and gynecology · 2015Article
- Maternal characteristics and mid-pregnancy serum biomarkers as risk factors for subtypes of preterm birth.BJOG : an international journal of obstetrics and gynaecology · 2015Article
- Changes in antimüllerian hormone levels in early pregnancy are associated with preterm birth.Fertility and sterility · 2015Article
- Maternal serum markers, characteristics and morbidly adherent placenta in women with previa.Journal of perinatology : official journal of the California Perinatal Association · 2015Article
- Population-based biomarker screening and the development of severe preeclampsia in California.American journal of obstetrics and gynecology · 2014Article
- Combined elevated midpregnancy tumor necrosis factor alpha and hyperlipidemia in pregnancies resulting in early preterm birth.American journal of obstetrics and gynecology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe purpose of this study was to examine the relationship between typically measured prenatal screening biomarkers and early-preterm birth in euploid pregnancies. STUDY
designThe study included 345 early-preterm cases (<30 weeks of gestation) and 1725 control subjects who were drawn from a population-based sample of California pregnancies who had both first- and second-trimester screening results. Logistic regression analyses were used to compare patterns of biomarkers in cases and control subjects and to develop predictive models. Replicability of the biomarker early-preterm relationships that was revealed by the models was evaluated by examination of the frequency and associated adjusted relative risks (RRs) for early-preterm birth and for preterm birth in general (<37 weeks of gestation) in pregnancies with identified abnormal markers compared with pregnancies without these markers in a subsequent independent California cohort of screened pregnancies (n = 76,588).
resultsThe final model for early-preterm birth included first-trimester pregnancy-associated plasma protein A in the ≤5th percentile, second-trimester alpha-fetoprotein in the ≥95th percentile, and second-trimester inhibin in the ≥95th percentile (odds ratios, 2.3-3.6). In general, pregnancies in the subsequent cohort with a biomarker pattern that were found to be associated with early-preterm delivery in the first sample were at an increased risk for early-preterm birth and preterm birth in general (<37 weeks of gestation; adjusted RR, 1.6-27.4). Pregnancies with ≥2 biomarker abnormalities were at particularly increased risk (adjusted RR, 3.6-27.4).
conclusionWhen considered across cohorts and in combination, abnormalities in routinely collected biomarkers reveal predictable risks for early-preterm birth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.