ArticleThe EMBO journal2013
Structural insights into the regulation of cohesion establishment by Wpl1.
Article in The EMBO journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Crosstalk between cohesins and axis proteins determines meiotic chromosome architecture in Sordaria macrospora.PLoS genetics · 2025Article
- Article
- ISW1a modulates cohesin distribution in centromeric and pericentromeric regions.Nucleic acids research · 2023Article
- PDS5A and PDS5B in Cohesin Function and Human Disease.International journal of molecular sciences · 2021Review
- Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Phosphatases in Mitosis: Roles and Regulation.Biomolecules · 2019Review
- Review
- New insights into cohesin loading.Current genetics · 2018Review
- Brca2, Pds5 and Wapl differentially control cohesin chromosome association and function.PLoS genetics · 2018Article
- A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.EMBO reports · 2018Article
- The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast.Nucleic acids research · 2017Article
- In Favor of Establishment: Regulation of Chromatid Cohesion in Plants.Frontiers in plant science · 2017Review
- Structural Insights into Ring Formation of Cohesin and Related Smc Complexes.Trends in cell biology · 2016Review
- Topology and structure of an engineered human cohesin complex bound to Pds5B.Nature communications · 2016Article
- Cohesin Releases DNA through Asymmetric ATPase-Driven Ring Opening.Molecular cell · 2016Article
- The Opposing Actions of Arabidopsis CHROMOSOME TRANSMISSION FIDELITY7 and WINGS APART-LIKE1 and 2 Differ in Mitotic and Meiotic Cells.The Plant cell · 2016Article
- Chromosome Dynamics during Mitosis.Cold Spring Harbor perspectives in biology · 2015Review
- Structure and function of cohesin's Scc3/SA regulatory subunit.FEBS letters · 2014Article
- Cohesin's ATPase activity couples cohesin loading onto DNA with Smc3 acetylation.Current biology : CB · 2014Article
- Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.Nature structural & molecular biology · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Correct segregation of duplicated chromosomes to daughter cells during mitosis requires the action of the cohesin complex. This tripartite ring-shaped molecule is involved in holding replicated sister chromatids together from S phase until anaphase onset. Establishment of stable cohesion involves acetylation of the Smc3 component of cohesin during replication by the Eco1 acetyltransferase. This has been proposed to antagonise the activity of another member of the cohesin complex, Wpl1. Here, we describe the X-ray structure of the conserved Wapl domain, and demonstrate that it binds the ATPase head of the Smc3 protein. We present data that suggest that Wpl1 may be involved in regulating the ATPase activity of cohesin, and that this may be subject to the acetylation state of Smc3. In addition, we present a structure of the Wapl domain bound to a functionally relevant segment of the Smc3 ATPase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.