ArticleWorld neurosurgery2013
Adult cerebellar glioblastoma: understanding survival and prognostic factors using a population-based database from 1973 to 2009.
Article in World neurosurgery, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Cerebellar glioblastoma in adults: a comparative single-center matched pair analysis and systematic review of the literature.Journal of cancer research and clinical oncology · 2024Pooled it
- Differences in regional developmental origins of glioblastomas revealed by integrated molecular profiling.Journal of neuro-oncology · 2026Article
- Letter to the editor regarding: "Recurrence patterns and clinical outcomes in adult cerebellar glioblastoma".Acta neurochirurgica · 2025Article
- Recurrence patterns and clinical outcomes in adult cerebellar glioblastoma.Acta neurochirurgica · 2025Article
- Racial and social-economic inequalities in systemic chemotherapy use among adult glioblastoma patients following surgery and radiotherapy.Scientific reports · 2024Article
- Clinical features and treatment of apoplectic intratumoral hemorrhage of glioma.BMC neurology · 2024Article
- Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas.BMC cancer · 2024Article
- A Synopsis of Biomarkers in Glioblastoma: Past and Present.Current issues in molecular biology · 2024Review
- Isocitrate Dehydrogenase (IDH)-Mutant High-Grade Glioma in the Cerebellum: A Case Report.Cureus · 2024Article
- Cerebellopontine angle pilocytic astrocytoma in adults: A systematic review.Surgical neurology international · 2024Review
- OLIG2 expression level could be used as an independent prognostic factor for patients with cerebellar Glioblastoma (cGBM).Clinics (Sao Paulo, Brazil) · 2023Article
- Review
- Characteristics and management of hydrocephalus in adult patients with cerebellar glioblastoma: lessons from a French nationwide series of 118 cases.Neurosurgical review · 2022Article
- Article
- Nomograms for predicting the overall survival of patients with cerebellar glioma: an analysis of the surveillance epidemiology and end results (SEER) database.Scientific reports · 2021Article
- Management, functional outcomes and survival in a French multicentric series of 118 adult patients with cerebellar glioblastoma.Journal of cancer research and clinical oncology · 2021Article
- Targeting Protein Kinase C in Glioblastoma Treatment.Biomedicines · 2021Review
- The many faces of glioblastoma: Pictorial review of atypical imaging features.The neuroradiology journal · 2021Review
- Outcomes of infratentorial cranial surgery for tumor resection in older patients: An analysis of the National Surgical Quality Improvement Program.Surgical neurology international · 2021Article
- Treatment patterns and outcomes for cerebellar glioblastoma in the concomitant chemoradiation era: A National Cancer database study.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Article
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6 authors at 3 institutions in 2 countries.
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Abstract
objectiveGlioblastoma (GB) is rarely found in the cerebellum. Because of its rarity, it is poorly understood if cerebellar GB (CGB) behaves similarly to supratentorial GB. Studies have been limited to case reports and small case series. A better understanding of CGB may help guide treatment strategies.
methodsSurveillance, Epidemiology and End Results database was analyzed from 1973 to 2009 for all adult patients with GB located in the cerebellum. Stepwise multivariate proportional hazards regression analyses were used to identify factors independently associated with survival.
resultsTwo hundred eight (0.9%) patients with CGB were identified from 23,329 GB patients with known locality. The mean age was 58 years. Median survival was 8 months, with 1-, 2- and 5-year survival rates of 21%, 13%, and 2%. When compared to supratentorial GB, CGB occurred in younger patients (58 ± 16 vs. 61 ± 13 years, P = 0.001), less commonly in Whites (85.6% vs. 91.3%, P = 0.005), and were smaller (3.7 ± 1.1 vs. 4.5 ± 1.7 cm, P = 0.001). A cerebellar location independently predicted poorer survival when compared to other GB locations (P = 0.048). In multivariate analysis for patients with CGB, younger age (P < 0.001), Asian or Pacific Islander race (P = 0.046), and radiation therapy (P < 0.001) were independently associated with prolonged survival.
conclusionCGBs are difficult to analyze using institutional series because of their rarity. This study shows they are clinically different from supratentorial GB. Among patients with CGB, radiation therapy may prolong survival. This may help guide treatment strategies aimed at prolonging survival for patients with these extremely rare lesions.
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