Evidence map›Paper›PMID 23395653›Full record

ArticleBioorganic & medicinal chemistry letters2013

Chemical probes of a trisubstituted pyrrole to identify its protein target(s) in Plasmodium sporozoites.

Tyrell Towle, Isabell Chang, Isabel Chang, Robert J Kerns, Purnima Bhanot

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

  • Erratum issued
    Chang, Isabel [corrected to Chang, Isabell]
5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Tyrell TowleDivision of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, 115 S. Grand Ave., S311 PHAR, Iowa City, IA 52240, USA.
Isabell Chang
Isabel Chang
Robert J Kerns
Purnima Bhanot
Rutgers, The State University of New Jersey · USUniversity of Iowa · US

Funding

Predoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4M
Identification of the target of a compound that inhibits plasmodium sporozoitesR21AI094167 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI BHANOT, PURNIMA · 2012 to 2013
$436k
NIAID NIH HHS R21 AI094167NIGMS NIH HHS T32 GM067795
6 · The paper itself

Abstract

Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infection of mammalian hepatocytes by Plasmodium sporozoites, but the target of this agent is not known. In this study trisubstituted pyrrole derivatives with different substituents on a piperidinyl nitrogen were prepared. We determined if modifications of the piperidinyl nitrogen would accommodate a drug-biotin linking strategy for affinity purification of the trisubstituted pyrrole's target protein(s).

Indexed as

AnimalsHepatocytesNitrogenPiperidinesPlasmodiumProtozoan ProteinsPyrrolesSporozoitesNitrogenpiperidinePiperidinesProtozoan ProteinsPyrroles

Identifiers

PMID23395653
PMCPMC5509439
OpenAlexW1987876633

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.