ArticleNeuron2013
Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Blocking apoptosis promotes survival and alters developmental dynamics of human retinal ganglion cells in retinal organoids.Cell reports · 2026Article
- A timeline of structural and functional consequences to ipRGCs in a mouse model of Alzheimer's disease.Neurobiology of aging · 2026Article
- ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions.Stem cells international · 2025Article
- Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territories.Cell reports · 2024Article
- Optimization-Based Pairwise Interaction Point Process (O-PIPP): A Precise and Universal Retinal Mosaic Modeling Approach.Investigative ophthalmology & visual science · 2024Article
- Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territory.bioRxiv : the preprint server for biology · 2023Article
- Retinal self-organization: a model of retinal ganglion cells and starburst amacrine cells mosaic formation.Open biology · 2023Article
- Article
- Atoh7-independent specification of retinal ganglion cell identity.Science advances · 2021Article
- Diversity of intrinsically photosensitive retinal ganglion cells: circuits and functions.Cellular and molecular life sciences : CMLS · 2021Review
- Increased density and age-related sharing of synapses at the cone to OFF bipolar cell synapse in the mouse retina.The Journal of comparative neurology · 2020Article
- Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia.PLoS biology · 2019Article
- Target-Derived Neurotrophic Factor Deprivation Puts Retinal Ganglion Cells on Death Row: Cold Hard Evidence and Caveats.International journal of molecular sciences · 2019Review
- Complement Targets Newborn Retinal Ganglion Cells for Phagocytic Elimination by Microglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Ocular Clocks: Adapting Mechanisms for Eye Functions and Health.Investigative ophthalmology & visual science · 2018Review
- External light activates hair follicle stem cells through eyes via an ipRGC-SCN-sympathetic neural pathway.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Melanopsin Retinal Ganglion Cells Regulate Cone Photoreceptor Lamination in the Mouse Retina.Cell reports · 2018Article
- Article
- Skilled Movements Require Non-apoptotic Bax/Bak Pathway-Mediated Corticospinal Circuit Reorganization.Neuron · 2017Article
- The Thymus/Neocortex Hypothesis of the Brain: A Cell Basis for Recognition and Instruction of Self.Frontiers in cellular neuroscience · 2017Article
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Authors and funding
16 authors.
Funding
Abstract
The retina consists of ordered arrays of individual types of neurons for processing vision. Here, we show that such order is necessary for intrinsically photosensitive retinal ganglion cells (ipRGCs) to function as irradiance detectors. We found that during development, ipRGCs undergo proximity-dependent Bax-mediated apoptosis. Bax mutant mice exhibit disrupted ipRGC spacing and dendritic stratification with an increase in abnormally localized synapses. ipRGCs are the sole conduit for light input to circadian photoentrainment, and either their melanopsin-based photosensitivity or ability to relay rod/cone input is sufficient for circadian photoentrainment. Remarkably, the disrupted ipRGC spacing does not affect melanopsin-based circadian photoentrainment but severely impairs rod/cone-driven photoentrainment. We demonstrate reduced rod/cone-driven cFos activation and electrophysiological responses in ipRGCs, suggesting that impaired synaptic input to ipRGCs underlies the photoentrainment deficits. Thus, for irradiance detection, developmental apoptosis is necessary for the spacing and connectivity of ipRGCs that underlie their functioning within a neural network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.