Evidence map›Paper›PMID 23395351›Full record

ReviewCurrent opinion in microbiology2013

Genomic transition of enterococci from gut commensals to leading causes of multidrug-resistant hospital infection in the antibiotic era.

Michael S Gilmore, Francois Lebreton, Willem van Schaik

Open access · hybridAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 303 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Article
  13. Clinical impact and risk factors of enterococcal bacteremia in children: a focus on vancomycin resistance and mortality.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  14. Article
  15. Article
  16. Insights into ecology, pathogenesis, and biofilm formation ofMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  17. Antimicrobial Susceptibility Profiles of CommensalAntibiotics (Basel, Switzerland) · 2025
    Article
  18. Article
  19. Article
  20. Observational

86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 3 countries.

Michael S GilmoreDepartment of Ophthalmology, Harvard Medical School, 243 Charles St., Boston, MA 02114, USA. michael_gilmore@meei.harvard.edu
Francois Lebreton
Willem van Schaik
Harvard University · US

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Johan Paulsson · 2009 to 2026
$39.4M
E. faecalis Pathogenicity IslandR01AI072360 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI GILMORE, MICHAEL S · 2007 to 2017
$3.8M
NIAID NIH HHS AI072360NIAID NIH HHS AI083214NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI072360
6 · The paper itself

Abstract

The enterococci evolved over eons as highly adapted members of gastrointestinal consortia of a wide variety of hosts, but for reasons that are not entirely clear, emerged in the 1970s as leading causes of multidrug resistant hospital infection. Hospital-adapted pathogenic isolates are characterized by the presence of multiple mobile elements conferring antibiotic resistance, as well as pathogenicity islands, capsule loci and other variable traits. Enterococci may have been primed to emerge among the vanguard of antibiotic resistant strains because of their occurrence in the GI tracts of insects and simple organisms living and feeding on organic matter that is colonized by antibiotic resistant, antibiotic producing micro-organisms. In response to the opportunity to inhabit a new niche--the antibiotic treated hospital patient--the enterococcal genome is evolving in a pattern characteristic of other bacteria that have emerged as pathogens because of opportunities stemming from anthropogenic change.

Indexed as

Drug Resistance, Multiple, BacterialAnti-Bacterial AgentsCarrier StateCross InfectionEnterococcusEvolution, MolecularGastrointestinal TractGene Transfer, HorizontalGram-Positive Bacterial InfectionsHumansInterspersed Repetitive SequencesVirulence FactorsAnti-Bacterial AgentsVirulence Factors

Identifiers

PMID23395351
PMCPMC3649759
OpenAlexW2078994321

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.