ArticleBiological psychiatry2013
Sex differences in familiality effects on neurocognitive performance in schizophrenia.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Heritability of Neuropsychological Measures in Schizophrenia and Nonpsychiatric Populations: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2017Pooled it
- Sex differences in higher-order cognition in schizophrenia and unaffected first-degree relatives: a longitudinal, family study.European archives of psychiatry and clinical neuroscience · 2026Article
- Genetic risk for schizophrenia and brain activation during the Penn Conditional Exclusion Test: A multiplex extended pedigree study.Journal of psychopathology and clinical science · 2025Article
- Neurocognitive functioning during adolescence: Spanish validation of the Penn Computerized Neurocognitive Battery.International journal of methods in psychiatric research · 2024Article
- Heritability of quantitative autism spectrum traits in adults: A family-based study.Autism research : official journal of the International Society for Autism Research · 2021Article
- Polygenic risk score increases schizophrenia liability through cognition-relevant pathways.Brain : a journal of neurology · 2019Article
- Sex differences in brain and behavior in adolescence: Findings from the Philadelphia Neurodevelopmental Cohort.Neuroscience and biobehavioral reviews · 2016Review
- Negative symptoms in youths with psychosis spectrum features: complementary scales in relation to neurocognitive performance and function.Schizophrenia research · 2015Article
- Consortium on the Genetics of Schizophrenia (COGS) assessment of endophenotypes for schizophrenia: an introduction to this Special Issue of Schizophrenia Research.Schizophrenia research · 2015Review
- Neurocognitive performance in family-based and case-control studies of schizophrenia.Schizophrenia research · 2015Article
- Olfaction in eating disorders and abnormal eating behavior: a systematic review.Frontiers in psychology · 2015Review
- Neurocognitive development in 22q11.2 deletion syndrome: comparison with youth having developmental delay and medical comorbidities.Molecular psychiatry · 2014Article
- Comparison of the heritability of schizophrenia and endophenotypes in the COGS-1 family study.Schizophrenia bulletin · 2014Article
- Exposure to herpes simplex virus, type 1 and reduced cognitive function.Journal of psychiatric research · 2013Article
Corrections and comments
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Authors and funding
22 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundNumerous studies have documented that patients with schizophrenia show neurocognitive impairments, which are also heritable in schizophrenia families. In view of these findings, the current investigation tested the hypothesis that neurocognitive performance of schizophrenia probands can predict the neurocognitive performance of their unaffected family members.
methodsParticipants (n=1967; schizophrenia=369; first-degree relatives=1072; community comparison subjects=526) in the Consortium on the Genetics of Schizophrenia were administered the Penn Computerized Neurocognitive Battery.
resultsConsistent with prior work, probands showed significant neurocognitive impairment, and neurocognitive ability was significantly heritable across domains. On average, unaffected relatives did not differ from community comparison subjects in their neurocognitive performance. However, in six of seven domains, proband scores predicted the performance of their unaffected siblings. Male, but not female, proband performance was predictive of their unaffected relatives' (siblings and mothers) performance, most consistently in face memory and spatial processing.
conclusionsUsing a novel approach in which individual probands are paired with their respective unaffected relatives within each family, we found that male proband performance predicted both sister and brother performance, an effect that was most powerfully observed for face memory and spatial processing. Results suggest that the familial transmission of sexually dimorphic neurocognitive domains, in which a particular sex tends to show a performance advantage over the other, may not itself be sex specific in schizophrenia families.
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