ReviewLancet (London, England)2013
Frailty in elderly people.
Review in Lancet (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 22 registered trials, which are not on this map. Cited by 4,542 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Superoxide Dismutase (SOD) Enzyme on Frailty and Health Related Quality of Life Among Indonesian Pre-frail Elderly: A Double Blind Randomized Controlled Trial
The Effects of a Multi-component Intervention on the Functional Capacity, Upper and Lower-body Muscle Strength, Balance and Gait in Frail Community-dwelling Older People: a Randomized Clinical Trial
Are Care Given by a Geriatric Hospital-Based Out Patient-Care Team Better Than Usual Care? - a Randomised Controlled Trial (The GerOP-Ca-trial)
MIND&GAIT - Promoting Independent Living in Frail Older Adults by Improving Cognition and Gait Ability and Using Assistive Products
'Comprehensive Geriatric Assessment' for Older Adults With Frailty Within Primary Care Setting: A Randomised Feasibility Trial
Use of Autologous Stem/Stromal Cellular Stromal Vascular Fraction (cSVF) In Cases Of Frailty and Aging Processes Using Autologous Stem-Stromal Cell Infusion in Patients With Aging Frailty And Wellness
Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes
Validation of a Record-based Frailty Assessment According to the Multidimensional Prognostic Index
Frailty Assessment by Edmonton Frail Scale to Predict Outcome in Patients Undergoing Cardiovascular Surgery "Frail Heart" Study.
Comparing the Association of Different Frailty Scores to the Incidence of Post-operative Delirium and Cognitive Dysfunction
Relationship Between Frailty and Clinical Outcomes in Elderly Patients With COVID-19
Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty
Study of an Intraoperative Frontal Electroencephalographic Marker of Preoperative Frailty in Patients Over 65 Years of Age for Elective Non-cardiac Surgery.
Prehabilitation in Patients With Gynaecological Cancer Planned for Postponed Surgical Management: A Prospective Randomised Trial.
PRecisiOn MEdicine to Target Frailty of Endocrine-metabolic Origin
Comprehensive Geriatric Assessment in the Emergency Department: a Prospective Cohort Study of Clinical and Process Outcomes
Does the Nutritionist's Educational Intervention Influence Protein Intake in Hospitalized Elderly People?
Influence of Frailty on Cardiovascular Events and Mortality in Patients With Chronic Obstructive Pulmonary Disease (COPD): A Multicentre Observational Study.
An Exploratory Analysis of a Frailty Management Program: Identifying Characteristics Associated With Improved Physical Performance Following a Combined Nutrition and Exercise Intervention in Hospitalized Frail Older Adults
Mortality Predictors After Major Abdominal Surgery in Patients Aged 80 and Over: The Role of Frailty and Physiological Reserve
Observational Study of Functional Changes and Fall Risk in Older Adults Participating in a Multicomponent Frailty and Falls Prevention Program in Primary Care
Clinical Efficacy of a Multicomponent Exercise and Comprehensive Geriatric Assessment Program (FRAIL+AP) in Frail Older Adults Within Primary Care: A Randomized Controlled Trial
Who cites it
4,542 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Planned Antihypertensive Deprescribing in Long-Term Care Residents: A Systematic Review of Randomized Evidence.Drugs & aging · 2026Pooled it
- Emergency department revisits and hospital readmissions following a fall-related emergency department presentation in older adults: a systematic review and meta-analysis.Age and ageing · 2026Pooled it
- Preoperative risk factors for postoperative pneumonia in patients with esophageal cancer: A systematic review and meta-analysis.Surgery today · 2026Pooled it
- Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review.International journal of molecular sciences · 2026Pooled it
- Association between oral frailty and physical frailty among older adults: a meta-analysis.BMC oral health · 2026Pooled it
- Age Is an Effect Modifier of Thrombectomy Benefit in a Socioeconomically Vulnerable Stroke Population.Annals of neurology · 2026Trial
- Assessing a Digital Platform (KOKU-Nut) to Improve Nutrition in Older Adults: Mixed Methods Feasibility Randomized Controlled Trial.JMIR aging · 2026Trial
- Influence of a Multicomponent Supervised Exercise Program on Frail and Prefrail Community-Dwelling Older Adults: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Trial
- Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.Journal of microbiology and biotechnology · 2026Trial
- Clinical immunogenicity in rAAV gene therapy: Insights and implications.Molecular therapy. Advances · 2026Review
- Prognostic value of different electrocardiographic criteria for left ventricular hypertrophy in Chinese community-dwelling older adults.International journal of cardiology. Heart & vasculature · 2026Article
- Mapping the future: Two decades of insights into preoperative frailty assessment in elderly patients.Dialogues in health · 2026Article
- Serum metabolomic signatures associated with frailty-related phenotypes in a cohort of older people.GeroScience · 2026Article
- The application of welfare technology in preventing solitary death among frail older adults who have lost their only child: A qualitative study based on the experiences of home help service providers.Dialogues in health · 2026Article
- Drivers of avoidable emergency department visits in older adults with multiple long-term conditions and palliative care needs: a qualitative survey across six care providers.Scandinavian journal of primary health care · 2026Article
- Hypertension management in the oldest-old: a survey of physicians in Swedish primary health care.Scandinavian journal of primary health care · 2026Article
- Feasibility and acceptability of the Health Assessment Tool (HAT) in Swedish primary care: insights into older patients' needs and professional perspectives.Scandinavian journal of primary health care · 2026Article
- Electromyographic findings and frailty in hemodialysis vs peritoneal dialysis patients.Renal failure · 2026Article
- Recognise, respond, reflect: A value-based framework for rapid response teams.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Examining Functional Limitation Trajectories Among Adults Experiencing Homelessness Versus the General Adult Population in Los Angeles County.American journal of preventive medicine · 2026Article
4,482 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Frailty is the most problematic expression of population ageing. It is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. This cumulative decline depletes homoeostatic reserves until minor stressor events trigger disproportionate changes in health status. In landmark studies, investigators have developed valid models of frailty and these models have allowed epidemiological investigations that show the association between frailty and adverse health outcomes. We need to develop more efficient methods to detect frailty and measure its severity in routine clinical practice, especially methods that are useful for primary care. Such progress would greatly inform the appropriate selection of elderly people for invasive procedures or drug treatments and would be the basis for a shift in the care of frail elderly people towards more appropriate goal-directed care.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.