ArticleBMC developmental biology2013
Thyroid hormone increases fibroblast growth factor receptor expression and disrupts cell mechanics in the developing organ of corti.
Article in BMC developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- The Role of Thyroid Hormone Signaling in the Development and Pathophysiology of Hearing: From Molecular Mechanisms to Clinical Applications.International journal of molecular sciences · 2026Review
- Expression of S100β during mouse cochlear development.European journal of histochemistry : EJH · 2025Article
- Thyroxine Regulates the Opening of the Organ of Corti through Affecting P-Cadherin and Acetylated Microtubule.International journal of molecular sciences · 2022Article
- The Induction of Hypothyroidism during Gestation Decreases Outer Hair Cell Motility in Rat Offspring.International archives of otorhinolaryngology · 2022Article
- Association between SSNHL and Thyroid Diseases.International journal of environmental research and public health · 2020Article
- Expression of acetylated tubulin in the postnatal developing mouse cochlea.European journal of histochemistry : EJH · 2018Article
- Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.Endocrinology · 2015Article
- Long-term time lapse imaging of mouse cochlear explants.Journal of visualized experiments : JoVE · 2014Article
- Making sense with thyroid hormone--the role of T(3) in auditory development.Nature reviews. Endocrinology · 2013Review
- Mechanisms involved in hearing disorders of thyroid ontogeny: a literature review.Archives of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThyroid hormones regulate growth and development. However, the molecular mechanisms by which thyroid hormone regulates cell structural development are not fully understood. The mammalian cochlea is an intriguing system to examine these mechanisms, as cellular structure plays a key role in tissue development, and thyroid hormone is required for the maturation of the cochlea in the first postnatal week.
resultsIn hypothyroid conditions, we found disruptions in sensory outer hair cell morphology and fewer microtubules in non-sensory supporting pillar cells. To test the functional consequences of these cytoskeletal defects on cell mechanics, we combined atomic force microscopy with live cell imaging. Hypothyroidism stiffened outer hair cells and supporting pillar cells, but pillar cells ultimately showed reduced cell stiffness, in part from a lack of microtubules. Analyses of changes in transcription and protein phosphorylation suggest that hypothyroidism prolonged expression of fibroblast growth factor receptors, and decreased phosphorylated Cofilin.
conclusionsThese findings demonstrate that thyroid hormones may be involved in coordinating the processes that regulate cytoskeletal dynamics and suggest that manipulating thyroid hormone sensitivity might provide insight into the relationship between cytoskeletal formation and developing cell mechanical properties.
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