SynthesisBMC infectious diseases2013
Severe strongyloidiasis: a systematic review of case reports.
Synthesis in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
176 citing papers in PubMed, 6 syntheses or guidelines pooled it, 364 citations in OpenAlex.
- [Recommendations for the screening for infectious diseases, mental health, and female genital mutilation in immigrant patients seen in Primary Care].Atencion primaria · 2020Guideline
- Medical care for migrant children in Europe: a practical recommendation for first and follow-up appointments.European journal of pediatrics · 2019Guideline
- Morbidity Associated with ChronicThe American journal of tropical medicine and hygiene · 2019Pooled it
- Effectiveness of Screening and Treatment Approaches for Schistosomiasis and Strongyloidiasis in Newly-Arrived Migrants from Endemic Countries in the EU/EEA: A Systematic Review.International journal of environmental research and public health · 2018Pooled it
- Ivermectin versus albendazole or thiabendazole for Strongyloides stercoralis infection.The Cochrane database of systematic reviews · 2016Pooled it
- Prevalence of strongyloidiasis in Latin America: a systematic review of the literature.Epidemiology and infection · 2015Pooled it
- Diagnostic Accuracy of a Novel Chemiluminescent Immunoassay forDiagnostics (Basel, Switzerland) · 2026Article
- Serodiagnosis of Human Strongyloidiasis in Brazil and Peru Using Strongyloides venezuelensis Antigens: A Comparative Study in Endemic Settings.Parasite immunology · 2026Article
- Eosinophilic Ascites: An Underrecognized Entity in Peritoneal Disorders.Digestive diseases and sciences · 2026Review
- Spotlighting zoonotic strongyloidiasis: a semi-systematic review of threadworms within baboons highlights opportunities for human infections.Infectious diseases of poverty · 2026Review
- Assessment of Two Commercial Serological Assays for the Diagnosis and Post-Treatment Follow-Up of Strongyloidiasis in a Cohort of Patients with Chagas Disease.Pathogens (Basel, Switzerland) · 2026Article
- Strongyloides stercoralis infection in patients presenting with lower respiratory tract infections: a retrospective case series from a tertiary hospital in Vietnam.BMC infectious diseases · 2026Article
- Colonic Strongyloides stercoralis With Multimodality Imaging, Endoscopic, and Histopathologic Correlation.Cureus · 2026Article
- Co-endemicity of Opisthorchis viverrini and Strongyloides stercoralis infections: evidence from stool examination and serology screening in Champasak Province, Southern Lao People's Democratic Republic.Parasitology research · 2026Article
- Seroprevalence and Associated Factors of Anti-Pathogens (Basel, Switzerland) · 2026Article
- Neuronally sensed oxygen drives behavior and development in human-infective, skin-penetrating nematodes.bioRxiv : the preprint server for biology · 2026Article
- An unusual presentation of strongyloidiasis in a patient on chronic dialysis causing clinical deterioration.BMC nephrology · 2026Article
- Predictors of severe strongyloidiasis and mortality in hospitalized patients from Southern Thailand.PLoS neglected tropical diseases · 2026Article
- The potential threat of Strongyloides spp. to mountain gorillas and public health in Bwindi Impenetrable National Park, Uganda.Parasitology research · 2026Article
- Article
116 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStrongyloidiasis is commonly a clinically unapparent, chronic infection, but immuno suppressed subjects can develop fatal disease. We carried out a review of literature on hyperinfection syndrome (HS) and disseminated strongyloidiasis (DS), in order to describe the most challenging aspects of severe strongyloidiasis.
methodsWe conducted a structured search using PubMed to collect case reports and short case series on HS/DS published from 1991 to 2011. We restricted search to papers in English, Spanish, Italian and French. Case reports were classified as HS/DS according to given definitions.
resultsRecords screened were 821, and 311 were excluded through titles and abstract evaluation. Of 510 full-text articles assessed for eligibility, 213 were included in qualitative analysis. As some of them were short case series, eventually the number of cases analyzed was 244.Steroids represented the main trigger predisposing to HS and DS (67% cases): they were mostly administered to treat underlying conditions (e.g. lymphomas, rheumatic diseases). However, sometimes steroids were empirically prescribed to treat signs and symptoms caused by unsuspected/unrecognized strongyloidiasis. Diagnosis was obtained by microscopy examination in 100% cases, while serology was done in a few cases (6.5%). Only in 3/29 cases of solid organ/bone marrow transplantation there is mention of pre-transplant serological screening. Therapeutic regimens were different in terms of drugs selection and combination, administration route and duration. Similar fatality rate was observed between patients with DS (68.5%) and HS (60%).
conclusionsProper screening (which must include serology) is mandatory in high - risk patients, for instance candidates to immunosuppressive medications, currently or previously living in endemic countries. In some cases, presumptive treatment might be justified. Ivermectin is the gold standard for treatment, although the optimal dosage is not clearly defined in case of HS/DS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.