ArticleBMC infectious diseases2013
Clinical and laboratory features that discriminate dengue from other febrile illnesses: a diagnostic accuracy study in Rio de Janeiro, Brazil.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 72 citations in OpenAlex.
- Diagnostic accuracy of the WHO clinical definitions for dengue and implications for surveillance: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2021Pooled it
- A meta-analysis of the diagnostic accuracy of two commercial NS1 antigen ELISA tests for early dengue virus detection.PloS one · 2014Pooled it
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- Integration of population-level data sources into an individual-level clinical prediction model for dengue virus test positivity.Science advances · 2024Article
- Diagnostic performance of the WHO definition of probable dengue within the first 5 days of symptoms on Reunion Island.PloS one · 2024Article
- Comprehensive diagnostic testing identifies diverse aetiologies of acute febrile illness among hospitalised children and adults in Sri Lanka: a prospective cohort study.BMJ public health · 2023Article
- The Effect of Age on Dengue Presentation and the Diagnostic Accuracy of the 2015 Pan American Health Organization Case Criteria in a Puerto Rican Cohort.Open forum infectious diseases · 2023Article
- Article
- Development and validation of a clinical rule for the diagnosis of chikungunya fever in a dengue-endemic area.PloS one · 2023Article
- Contribution of Viral Respiratory Infections to Dengue-Like Illness Presentation at a Community Clinic in Southern Malaysia.The American journal of tropical medicine and hygiene · 2021Article
- Rapid testing requires clinical evaluation for accurate diagnosis of dengue disease: A passive surveillance study in Southern Malaysia.PLoS neglected tropical diseases · 2021Article
- Epidemiological and clinical analysis of the outbreak of dengue fever in Zhangshu City, Jiangxi Province, in 2019.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- False-positive dengue IgM test result in a patient with systemic lupus erythematosus: a case report.Asian biomedicine : research, reviews and news · 2020Article
- Dengue Infection in Children in Fortaleza, Brazil: A 3-Year School-Based Prospective Cohort Study.The American journal of tropical medicine and hygiene · 2020Article
- Development and Performance of Dengue Diagnostic Clinical Algorithms in Colombia.The American journal of tropical medicine and hygiene · 2020Article
- Etiologies of Acute Undifferentiated Febrile Illness in Bangkok, Thailand.The American journal of tropical medicine and hygiene · 2019Article
- Diagnostic Value of Platelet and Leukocyte Counts in the Differential Diagnosis of Fever in the Returning Traveler.The American journal of tropical medicine and hygiene · 2019Article
- Accuracy of dengue clinical diagnosis with and without NS1 antigen rapid test: Comparison between human and Bayesian network model decision.PLoS neglected tropical diseases · 2018Article
- Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic.PLoS neglected tropical diseases · 2018Article
- Prospective evaluation of the SD BIOLINE Dengue Duo rapid test during a dengue virus epidemic.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDengue is an acute febrile illness caused by an arbovirus that is endemic in more than 100 countries. Early diagnosis and adequate management are critical to reduce mortality. This study aims to identify clinical and hematological features that could be useful to discriminate dengue from other febrile illnesses (OFI) up to the third day of disease.
methodsWe conducted a sectional diagnostic study with patients aged 12 years or older who reported fever lasting up to three days, without any evident focus of infection, attending an outpatient clinic in the city of Rio de Janeiro, Brazil, between the years 2005 and 2008. Logistic regression analysis was used to identify symptoms, physical signs, and hematological features valid for dengue diagnosis. Receiver-operating characteristic (ROC) curve analyses were used to define the best cut-off and to compare the accuracy of generated models with the World Health Organization (WHO) criteria for probable dengue.
resultsBased on serological tests and virus genome detection by polymerase chain reaction (PCR), 69 patients were classified as dengue and 73 as non-dengue. Among clinical features, conjunctival redness and history of rash were independent predictors of dengue infection. A model including clinical and laboratory features (conjunctival redness and leukocyte counts) achieved a sensitivity of 81% and specificity of 71% and showed greater accuracy than the WHO criteria for probable dengue.
conclusionsWe constructed a predictive model for early dengue diagnosis that was moderately accurate and performed better than the current WHO criteria for suspected dengue. Validation of this model in larger samples and in other sites should be attempted before it can be applied in endemic areas.
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