Evidence map›Paper›PMID 23394158›Full record

ArticleNanomedicine (London, England)2013

Biotargeted nanomedicines for cancer: six tenets before you begin.

Michael S Goldberg, Sara S Hook, Andrew Z Wang, Jeff W M Bulte, Anil K Patri, Fatih M Uckun, Vincent L Cryns, Justin Hanes, Demir Akin, Jennifer B Hall and 2 more

Abstract read
In one paragraph

Article in Nanomedicine (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 55 citations in OpenAlex.

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  17. Personalized medicine in hematology - A landmark from bench to bed.Computational and structural biotechnology journal · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Michael S GoldbergDana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.
Sara S Hook
Andrew Z Wang
Jeff W M Bulte
Anil K Patri
Fatih M Uckun
Vincent L Cryns
Justin Hanes
Demir Akin
Jennifer B Hall
Nastaran Gharkholo
Russell J Mumper
National Cancer Institute · USUniversity of North Carolina at Chapel Hill · USChildren's Hospital of Los Angeles · USHarvard University · USJohns Hopkins University · USOffice of the Director · USStanford University · USUniversity of Wisconsin–Madison · US

Funding

Targeting SYK Kinase in B-Lineage ALL with CD19-Specific C-61 NanoparticlesU01CA151837 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2010 to 2014
$2.3M
Tumor Targeted Nanobins for the Treatment of Metastatic Breast and Ovarian CancerU01CA151461 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI O'HALLORAN, THOMAS V · 2010 to 2014
$2.2M
Targeting SYK Tyrosine Kinase to Overcome Radiation Resistance in ALLR01CA154471 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2011 to 2015
$1.6M
Nanoparticle formulations of DNA repair inhibitors to improve chemoradiotherapyR01CA178748 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WANG, ANDREW ZHUANG · 2013 to 2017
$1.6M
Amplifying Radiation Potency Against Leukemic Stem CellsR21CA164098 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI UCKUN, FATIH M · 2012 to 2013
$377k
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCI NIH HHS R01 CA154471NCI NIH HHS R01 CA178748NCI NIH HHS R21 CA164098NCI NIH HHS U01 CA151461NCI NIH HHS U01 CA151837
6 · The paper itself

Abstract

Biotargeted nanomedicines have captured the attention of academic and industrial scientists who have been motivated by the theoretical possibilities of the 'magic bullet' that was first conceptualized by Paul Ehrlich at the beginning of the 20th century. The Biotargeting Working Group, consisting of more than 50 pharmaceutical scientists, engineers, biologists and clinicians, has been formed as part of the National Cancer Institute's Alliance for Nanotechnology in Cancer to harness collective wisdom in order to tackle conceptual and practical challenges in developing biotargeted nanomedicines for cancer. In modern science and medicine, it is impossible for any individual to be an expert in every aspect of biology, chemistry, materials science, pharmaceutics, toxicology, chemical engineering, imaging, physiology, oncology and regulatory affairs. Drawing on the expertise of leaders from each of these disciplines, this commentary highlights six tenets of biotargeted cancer nanomedicines in order to enable the translation of basic science into clinical practice.

Indexed as

NeoplasmsAnimalsHumansNanomedicine

Identifiers

PMID23394158
PMCPMC3643633
OpenAlexW2129895028

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.