ArticleBiomacromolecules2013
Hyperbranched polyester hydrogels with controlled drug release and cell adhesion properties.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 122 citations in OpenAlex.
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- Basement Membrane Mimetic Hydrogel Cooperates with Rho-Associated Protein Kinase Inhibitor to Promote the Development of Acini-Like Salivary Gland Spheroids.Advanced nanobiomed research · 2023Article
- Dendritic Polymers in Tissue Engineering: Contributions of PAMAM, PPI PEG and PEI to Injury Restoration and Bioactive Scaffold Evolution.Pharmaceutics · 2023Review
- Synthesis of Hydrogels and Their Progress in Environmental Remediation and Antimicrobial Application.Gels (Basel, Switzerland) · 2022Review
- Encapsulation of MSCs and GDNF in an Injectable Nanoreinforced Supramolecular Hydrogel for Brain Tissue Engineering.Biomacromolecules · 2022Article
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- Dynamic cross-linking of an alginate-acrylamide tough hydrogel system: time-resolvedRSC advances · 2021Article
- Synergistic enhancement of tendon-to-bone healing via anti-inflammatory and pro-differentiation effects caused by sustained release of MgTheranostics · 2021Article
- Photopolymerizable Biomaterials and Light-Based 3D Printing Strategies for Biomedical Applications.Chemical reviews · 2020Review
- Stimuli-Responsive Materials for Tissue Engineering and Drug Delivery.International journal of molecular sciences · 2020Review
- Novozym 435-Catalyzed Synthesis of Well-Defined Hyperbranched Aliphatic Poly(β-thioether ester).Molecules (Basel, Switzerland) · 2020Article
- Composite Hydrogels in Three-DimensionalFrontiers in bioengineering and biotechnology · 2020Review
- Preparation of Multiwall Carbon Nanotubes Embedded Electroconductive Multi-Microchannel Scaffolds for Neuron Growth under Electrical Stimulation.BioMed research international · 2020Article
- Formation of Monolithic Ion-Selective Transport Media Based on "Click" Cross-Linked Hyperbranched Polyglycerol.Frontiers in chemistry · 2019Article
- Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery.ACS biomaterials science & engineering · 2017Article
- A Bioinspired Alginate-Gum Arabic Hydrogel with Micro-/Nanoscale Structures for Controlled Drug Release in Chronic Wound Healing.ACS applied materials & interfaces · 2017Article
- Patterning Three-Dimensional Hydrogel Microenvironments Using Hyperbranched Polyglycerols for Independent Control of Mesh Size and Stiffness.Biomacromolecules · 2017Article
- In Situ-Forming Polyamidoamine Dendrimer Hydrogels with Tunable Properties Prepared via Aza-Michael Addition Reaction.ACS applied materials & interfaces · 2017Article
- Article
- Forming Spacers in Situ by Photolithography to Mechanically Stabilize Electrofluidic-Based Switchable Optical Elements.Materials (Basel, Switzerland) · 2016Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Hyperbranched polyesters (HPE) have a high efficiency to encapsulate bioactive agents, including drugs, genes, and proteins, due to their globe-like nanostructure. However, the use of these highly branched polymeric systems for tissue engineering applications has not been broadly investigated. Here, we report synthesis and characterization of photocrosslinkable HPE hydrogels with sustained drug release characteristics for cellular therapies. These HPE can encapsulate hydrophobic drug molecules within the HPE cavities due to the presence of a hydrophobic inner structure that is otherwise difficult to achieve in conventional hydrogels. The functionalization of HPE with photocrosslinkable acrylate moieties renders the formation of hydrogels with a highly porous interconnected structure and mechanically tough network. The compressive modulus of HPE hydrogels was tunable by changing the crosslinking density. The feasibility of using these HPE networks for cellular therapies was investigated by evaluating cell adhesion, spreading, and proliferation on hydrogel surface. Highly crosslinked and mechanically stiff HPE hydrogels have higher cell adhesion, spreading, and proliferation compared to soft and complaint HPE hydrogels. Overall, we showed that hydrogels made from HPE could be used for biomedical applications that require spatial control of cell adhesion and controlled release of hydrophobic clues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.