ArticleThe Australasian medical journal2011
Potential drug interactions in patients admitted to cardiology wards of a south Indian teaching hospital.
Article in The Australasian medical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 73 citations in OpenAlex.
- Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human volunteers of Karachi, Pakistan.PloS one · 2022Trial
- Potential drug-drug interactions in hospitalized patients with acute coronary syndrome at a tertiary care hospital in upper Egypt.Frontiers in pharmacology · 2026Article
- Potential drug-drug interactions among hospitalised cardiac patients in Nepal: a prospective observational study.BMJ open · 2025Observational
- Clinical Pertinence and Determinants of Potential Drug-Drug Interactions in Chronic Kidney Disease Patients: A Cross-sectional Study.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Article
- Assessment of Potential Drug-drug Interactions (pDDIs) and Their Risk Factors Among Hospitalized Cardiac Patients in a Tertiary-care Center of Central India: A Retrospective Record-based Study.Hospital pharmacy · 2024Article
- Potentially Harmful Drug-Drug Interactions and Their Associated Factors Among Hospitalized Cardiac Patients: A Cross-Sectional Study.Drugs - real world outcomes · 2023Article
- Potential Drug-Drug Interactions in a Cardiac Center: Development of Simple Software for Pattern Identification.The journal of Tehran Heart Center · 2022Article
- Developing a desktop application for drug-drug interaction checker ordered for chronic diseases in Ethiopian hospitals pharmacy.BMC pharmacology & toxicology · 2022Article
- Potential Drug-Drug Interactions in Hospitalized Medical Patients: Data From Low Resource Settings.Cureus · 2021Article
- Potential drug-drug interactions in patients with cardiovascular diseases: findings from a prospective observational study.Journal of pharmaceutical policy and practice · 2021Article
- Drug-drug interactions in patients with acute coronary syndrome across phases of treatment.Internal and emergency medicine · 2019Observational
- Follow-up and management of valvular heart disease patients with prosthetic valve: a clinical practice guideline for Indian scenario.Indian journal of thoracic and cardiovascular surgery · 2019Article
- Potential drug-drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia.SAGE open medicine · 2019Article
- Potential Drug-drug Interactions in Acute Ischemic Stroke Patients at the Neurological Intensive Care Unit.Open medicine (Warsaw, Poland) · 2019Article
- Detection and analysis of drug-drug interactions among hospitalized cardiac patients in the Mohammed V Military Teaching Hospital in Morocco.The Pan African medical journal · 2018Observational
- A Prospective Analysis of Drug Interactions in Patients of Intensive Cardiac Care Unit.Journal of clinical and diagnostic research : JCDR · 2017Article
- Potential drug-drug interactions among hospitalized patients in a developing country.Caspian journal of internal medicine · 2017Article
- Assessment of potential drug-drug interactions and its associated factors in the hospitalized cardiac patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2016Article
- Evaluation of potential drug - drug interactions in general medicine ward of teaching hospital in southern India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Evaluation of rationality in prescribing, adherence to treatment guidelines, and direct cost of treatment in intensive cardiac care unit: A prospective observational study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundThe potential drug-drug interaction (pDDI) increases as the number of concomitant medications increases. Patients with cardiovascular disorders are at higher risk for drug- drug interactions because of the types and number of drugs they receive. While drug interactions are reported to be common, there is no published report of the prevalence of such interactions among Indian cardiac patients. The aim of the present study was to identify the pattern of pDDI and document any observed interaction. It was also planned to evaluate the demography of patients and correlate it with the drug-drug interactions.
methodA prospective observational study from Oct 2007 to Apr 2008 was carried out in 'cardiology department' of a hospital in South India. Those patients who were taking at least two drugs and had a hospital stay of at least 48 hours were included in the study. The medications of the patients were analyzed for possible interactions. Factors associated with pDDI were studied. The actual interactions that were observed during the hospital stay in the study subjects were documented.
resultsA total of 812 patients were included in the study. 388 pDDIs were identified among 249 patients. The incidence of pDDI was 30.67%. The most common potential interactions were between aspirin & heparin (29.38%), and clopidogrel & heparin (7.21%). Drug classes most commonly involved were antiplatelets, anticoagulants and diuretics. Majority of interactions were of moderate severity, delayed onset, and pharmacodynamic in nature. Total 68 actual interactions were observed in the observed cases.
conclusionThe present study identified pDDIs and also documented interactions in cardiovascular patients. Factors which had correlation with adverse drug interactions were identified. This study highlights the need for screening prescriptions of cardiovascular patients for pDDIs and proactive monitoring of patients who have identified risk factors; this helps in detection and prevention of possible adverse drug interactions.
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