Molecular biology. Shielding broken DNA for a quick fix.

Jiri Lukas, Claudia Lukas

Abstract readComment

In one paragraph

Article in Science (New York, N.Y.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

Vanguard is a Glucose Deprivation-Responsive Long Non-Coding RNA Essential for Chromatin Remodeling-Reliant DNA Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
Article
The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells.Cells · 2022
Article
DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair.The Journal of cell biology · 2021
Article
OsMre11 Is Required for Mitosis during Rice Growth and Development.International journal of molecular sciences · 2020
Article
Radiosensitising Cancer Using Phosphatidylinositol-3-Kinase (PI3K), Protein Kinase B (AKT) or Mammalian Target of Rapamycin (mTOR) Inhibitors.Cancers · 2020
Review
Eltrombopag promotes DNA repair in human hematopoietic stem and progenitor cells.Experimental hematology · 2019
Article
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination.Molecular cell · 2017
Article
Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability.Molecular cell · 2016
Article
Variations in brain DNA.Frontiers in aging neuroscience · 2014
Review

4 · The record

Corrections and comments

Comment on
53BP1 regulates DSB repair using Rif1 to control 5' end resection.2013
Comment on
Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching.2013

5 · Who and what money

Authors and funding

2 authors.

Jiri LukasNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark. jiri.lukas@cpr.ku.dk

Claudia Lukas

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

DNA Breaks, Double-StrandedDNA RepairImmunoglobulin Class SwitchingAnimalsChromosomal Proteins, Non-HistoneDNADNA-Binding ProteinsTelomereTelomere-Binding ProteinsTumor Suppressor p53-Binding Protein 1Chromosomal Proteins, Non-HistoneDNADNA-Binding ProteinsRif1 protein, mouseTelomere-Binding ProteinsTrp53bp1 protein, mouseTumor Suppressor p53-Binding Protein 1

Identifiers

PMID23393250

DOI10.1126/science.1234602

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.