ArticleNucleic acids research2013
Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Pooled it
- Lipid droplet-associated hydrolase mobilizes stores of liver X receptor sterol ligands and protects against atherosclerosis.Nature communications · 2024Article
- NR1H3 (LXRα) is associated with pro-inflammatory macrophages, predicts survival and suggests potential therapeutic rationales in diffuse large b-cell lymphoma.Hematological oncology · 2022Article
- miR-1183 Is a Key Marker of Remodeling upon Stretch and Tachycardia in Human Myocardium.International journal of molecular sciences · 2022Article
- Integrative analysis reveals multiple modes of LXR transcriptional regulation in liver.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nuclear Receptors and Lipid Sensing.Advances in experimental medicine and biology · 2022Article
- The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD.Oxidative medicine and cellular longevity · 2021Review
- Motif grammar: The basis of the language of gene expression.Computational and structural biotechnology journal · 2020Review
- LXR/RXR signaling and neutrophil phenotype following myocardial infarction classify sex differences in remodeling.Basic research in cardiology · 2018Article
- Nuclear receptors in cancer - uncovering new and evolving roles through genomic analysis.Nature reviews. Genetics · 2018Review
- IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis.Scientific reports · 2018Article
- EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Transcriptional regulation of hepatic lipogenesis.Nature reviews. Molecular cell biology · 2015Review
- Decreased cholesterol uptake and increased liver x receptor-mediated cholesterol efflux pathways during prostaglandin F2 alpha-induced and spontaneous luteolysis in sheep.Biology of reproduction · 2015Article
- Liver X receptor-dependent inhibition of microglial nitric oxide synthase 2.Journal of neuroinflammation · 2015Article
- ChIP-seq profiling of the active chromatin marker H3K4me3 and PPARγ, CEBPα and LXR target genes in human SGBS adipocytes.Genomics data · 2014Article
- Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network.Nucleic acids research · 2014Article
- Network analysis of inflammatory genes and their transcriptional regulators in coronary artery disease.PloS one · 2014Article
- Protein sets define disease states and predict in vivo effects of drug treatment.Molecular & cellular proteomics : MCP · 2013Article
- Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks.Mediators of inflammation · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased physiological levels of oxysterols are major risk factors for developing atherosclerosis and cardiovascular disease. Lipid-loaded macrophages, termed foam cells, are important during the early development of atherosclerotic plaques. To pursue the hypothesis that ligand-based modulation of the nuclear receptor LXRα is crucial for cell homeostasis during atherosclerotic processes, we analysed genome-wide the action of LXRα in foam cells and macrophages. By integrating chromatin immunoprecipitation-sequencing (ChIP-seq) and gene expression profile analyses, we generated a highly stringent set of 186 LXRα target genes. Treatment with the nanomolar-binding ligand T0901317 and subsequent auto-regulatory LXRα activation resulted in sequence-dependent sharpening of the genome-binding patterns of LXRα. LXRα-binding loci that correlated with differential gene expression revealed 32 novel target genes with potential beneficial effects, which in part explained the implications of disease-associated genetic variation data. These observations identified highly integrated LXRα ligand-dependent transcriptional networks, including the APOE/C1/C4/C2-gene cluster, which contribute to the reversal of cholesterol efflux and the dampening of inflammation processes in foam cells to prevent atherogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.