ReviewMicrobiology (Reading, England)2013
Streptococcus mutans: a new Gram-positive paradigm?
Review in Microbiology (Reading, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does Curcumin Have an Anticaries Effect? A Systematic Review of In Vitro Studies.Advances in experimental medicine and biology · 2021Pooled it
- Development & assessment of polyherbal extracts for treating oral cancer by integrating phytochemistry, bioactivities, and network pharmacology.Scientific reports · 2026Article
- Article
- Safety-constrained evaluation of antibacterial multicomponent borate glasses.Biomaterials and biosystems · 2026Article
- Putative Prebiotics Can Disrupt 3D Architecture and Modulate the Microbial Population to Prevent Cariogenic Biofilm Build-Up In Vitro.ACS omega · 2026Article
- Preliminary In Vitro Evaluation of the Growth-Inhibitory Effects of Nigella sativa Oil on Streptococcus mutans.Cureus · 2026Article
- Prevalence of oral streptococci and glucosyltransferase genes in mother-child pairs: a cross-sectional study in Turkish families.BMC pediatrics · 2026Article
- AJournal of bacteriology · 2026Review
- Preparation of clove extract-loaded nano-hydroxyapatite for combating dental caries-associated microbes.The Saudi dental journal · 2026Article
- Raman signatures ofFrontiers in microbiology · 2026Article
- Raman signatures ofFrontiers in microbiology · 2026Article
- Oral dysbiosis: methodological evolution, the mobile resistome and the future of machine learning in dentistry.Journal of oral microbiology · 2026Review
- An efficient electrotransformation method for three Bacillus species.Applied microbiology and biotechnology · 2025Article
- Fluoride in Dental Caries Prevention and Treatment: Mechanisms, Clinical Evidence, and Public Health Perspectives.Healthcare (Basel, Switzerland) · 2025Review
- Review
- Oral Microbiome Dynamics in Treated Childhood Caries: A Comparative Study.Life (Basel, Switzerland) · 2024Article
- Corynebacterial membrane vesicles disrupt cariogenic interkingdom assemblages.Applied and environmental microbiology · 2024Article
- Ribosomal-processing cysteine protease homolog modulatesJournal of bacteriology · 2024Article
- Potential interaction of sugar intake and tobacco exposure on dental caries in adults-A cross-sectional study from the National Health and Nutrition Examination Survey.Journal of dental sciences · 2024Article
- A Color Indicator Based on 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide (MTT) and a Biodegradable Poly(ester amide) for Detecting Bacterial Contamination.International journal of molecular sciences · 2024Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Despite the enormous contributions of the bacterial paradigms Escherichia coli and Bacillus subtilis to basic and applied research, it is well known that no single organism can be a perfect representative of all other species. However, given that some bacteria are difficult, or virtually impossible, to cultivate in the laboratory, that some are recalcitrant to genetic and molecular manipulation, and that others can be extremely dangerous to manipulate, the use of model organisms will continue to play an important role in the development of basic research. In particular, model organisms are very useful for providing a better understanding of the biology of closely related species. Here, we discuss how the lifestyle, the availability of suitable in vitro and in vivo systems, and a thorough understanding of the genetics, biochemistry and physiology of the dental pathogen Streptococcus mutans have greatly advanced our understanding of important areas in the field of bacteriology such as interspecies biofilms, competence development and stress responses. In this article, we provide an argument that places S. mutans, an organism that evolved in close association with the human host, as a novel Gram-positive model organism.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.