ArticleEnvironmental science and pollution research international2013
Sub-inhibitory concentrations of antibiotics and wastewater influencing biofilm formation and gene expression of multi-resistant Pseudomonas aeruginosa wastewater isolates.
Article in Environmental science and pollution research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 58 citations in OpenAlex.
- Study on the persistence of ciprofloxacin and sulfamethoxazole in simulated drinking water systems.Environmental systems research · 2025Article
- Sub-inhibitory concentrations of tetrabromobisphenol A induce the biofilm formation of methicillin-resistant Staphylococcus aureus.Archives of microbiology · 2024Article
- Environmentally Relevant Antibiotic Concentrations Exert Stronger Selection Pressure on River Biofilm Resistomes than AMR-Reservoir Effluents.Antibiotics (Basel, Switzerland) · 2024Article
- Effects of Sub-Minimum Inhibitory Concentrations of Gentamicin on Alginate Produced by Clinical Isolates ofAdvanced biomedical research · 2023Article
- Gentamicin at sub-inhibitory concentrations selects for antibiotic resistance in the environment.ISME communications · 2022Article
- Different effects of sub-minimum inhibitory concentrations of gentamicin on the expression of genes involved in alginate production and biofilm formation ofIranian journal of microbiology · 2021Article
- Sub-Inhibitory Antibiotic Exposure and Virulence inAntibiotics (Basel, Switzerland) · 2021Review
- Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 11:EFSA journal. European Food Safety Authority · 2021Article
- Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance.Environmental science and pollution research international · 2021Review
- Environmental Biofilms as Reservoirs for Antimicrobial Resistance.Frontiers in microbiology · 2021Review
- Evaluating of the Effects of Sub-MIC Concentrations of Gentamicin on Biofilm Formation in Clinical Isolates ofIranian journal of pathology · 2021Article
- Identification of discriminatory antibiotic resistance genes among environmental resistomes using extremely randomized tree algorithm.Microbiome · 2019Article
- Overexpression of antibiotic resistance genes in hospital effluents over time.The Journal of antimicrobial chemotherapy · 2017Article
- Antimicrobial resistance of Pseudomonas spp. isolated from wastewater and wastewater-impacted marine coastal zone.Environmental science and pollution research international · 2015Article
- Tackling antibiotic resistance: the environmental framework.Nature reviews. Microbiology · 2015Review
- Article
- Effects of 100 years wastewater irrigation on resistance genes, class 1 integrons and IncP-1 plasmids in Mexican soil.Frontiers in microbiology · 2015Article
- Multi-channel microfluidic biosensor platform applied for online monitoring and screening of biofilm formation and activity.PloS one · 2015Article
- Antibiotic multiresistance analysis of mesophilic and psychrotrophic Pseudomonas spp. isolated from goat and lamb slaughterhouse surfaces throughout the meat production process.Applied and environmental microbiology · 2014Article
- Wastewater irrigation increases the abundance of potentially harmful gammaproteobacteria in soils in Mezquital Valley, Mexico.Applied and environmental microbiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sub-inhibitory concentrations of antibiotics, which are found in environmental water systems and sewage plants due to an increased use in therapeutical and preventive fields, influence bacterial behavior in biofilms. The application of sulfamethoxazole, erythromycin, and roxithromycin induced changes in biofilm dynamics regarding biomass formation, spatial structure and specific gene expression in different Pseudomonas aeruginosa isolates. Exposing multi-resistant environmental isolated strains for 17 h to environmental concentrations of antibiotics or wastewater, directly, an increase in biofilm biomass and thickness could be observed for each strain. Additionally, multi-resistant strains responded to the applied growth conditions with changes in transcriptional activity. Here, sub-inhibitory concentrations of macrolides specifically upregulated expression of quorum sensing genes (rhlR, lasI), whereas sulfonamides and municipal wastewater, instead upregulated expression of specific resistant genes (sul1) and efflux pumps (mexD). Antibiotic sensitive isolates demonstrated an overall higher transcriptionally activity, but did not show a specific gene response to the applied exogenous stimuli. Furthermore, the presence of low concentrated antibiotics induced also phenotypical change in the biofilm architecture observed by 3D-imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.