ArticleAdvances in experimental medicine and biology2013
Reduced placental taurine transporter (TauT) activity in pregnancies complicated by pre-eclampsia and maternal obesity.
Article in Advances in experimental medicine and biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 43 citations in OpenAlex.
- Placental endocrine function is controlled by maternal gut Bifidobacterium in germ-free mice.Journal of translational medicine · 2025Article
- Regulation of placental amino acid transport in health and disease.Acta physiologica (Oxford, England) · 2024Review
- Placental adaptations supporting fetal growth during normal and adverse gestational environments.Experimental physiology · 2023Review
- Placental Metabolomics of Fetal Growth Restriction.Metabolites · 2023Article
- Watermelon-Derived Extracellular Vesicles Influence Human Ex Vivo Placental Cell Behavior by Altering Intestinal Secretions.Molecular nutrition & food research · 2022Article
- Taurine: A Maternally Derived Nutrient Linking Mother and Offspring.Metabolites · 2022Review
- Identification of Biomarkers for Preeclampsia Based on Metabolomics.Clinical epidemiology · 2022Review
- Placental adaptations in a nonhuman primate model of gestational protein restriction.Journal of developmental origins of health and disease · 2021Article
- The effect of high glucose on lipid metabolism in the human placenta.Scientific reports · 2019Article
- Nutrient transporter expression in both the placenta and fetal liver are affected by maternal smoking.Placenta · 2019Article
- A systems perspective on placental amino acid transport.The Journal of physiology · 2018Review
- Placental Nutrient Transport and Intrauterine Growth Restriction.Frontiers in physiology · 2016Review
- PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth.Scientific reports · 2015Article
- Maternal obesity is associated with a reduction in placental taurine transporter activity.International journal of obesity (2005) · 2015Article
- Effects of taurine depletion on human placental syncytiotrophoblast renewal and susceptibility to oxidative stress.Advances in experimental medicine and biology · 2015Article
- Detrimental effects of ethanol and its metabolite acetaldehyde, on first trimester human placental cell turnover and function.PloS one · 2014Article
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7 authors at 2 institutions in 1 country.
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Abstract
Taurine is an important nutrient in intrauterine life, being required for fetal organ development and cellular renewal of syncytiotrophoblast (STB), the nutrient transport epithelium of the placenta. As taurine is conditionally essential in human pregnancy, the fetal and placental demand for taurine is met by uptake from maternal blood into STB through the activity of TauT. Pre-eclampsia (PE) and maternal obesity are serious complications of pregnancy, associated with fetal growth restriction (FGR) and abnormal renewal of STB, and maternal obesity is a major risk factor for PE. Here we test the hypothesis that STB TauT activity is reduced in maternal obesity and PE compared to normal pregnancy.STB TauT activity, measured in fragments of placental tissue, was negatively related to maternal BMI over the range 18-46 kg/m(2) in both the first trimester (7-12 weeks gestation) and at term (p < 0.01; linear regression). Neither TauT activity nor expression in the first trimester differed to normal pregnancy at term. STB TauT activity was significantly lower in PE than normal pregnancy (p < 0.01). Neuropeptide Y (NPY), a protein kinase C (PKC) activator which is elevated in PE and obesity, reduced STB TauT activity by 20% (50 pM-50 nM: 2 h) (p < 0.03). Activation of PKC by phorbol 12-myristate-13-acetate (1 μM) reduced TauT activity by 18% (p < 0.05). As TauT activity is inhibited by phosphorylation, we propose that NPY activates PKC in the STB which phosphorylates TauT in PE and maternal obesity.Reduced TauT activity could contribute to dysregulated renewal of STB and FGR that are common to PE and maternal obesity.
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