ArticleJournal of neuro-oncology2013
Expression of aquaporin 5 and the AQP5 polymorphism A(-1364)C in association with peritumoral brain edema in meningioma patients.
Article in Journal of neuro-oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Seizures in supratentorial meningioma: a systematic review and meta-analysis.Journal of neurosurgery · 2016Pooled it
- Peritumoral edema in meningiomas: a review of influencing factors, mechanisms, and management.Frontiers in oncology · 2026Review
- Role of aquaporins in brain water transport and edema.Frontiers in neuroscience · 2025Review
- Article
- Aquaporins: Gatekeepers of Fluid Dynamics in Traumatic Brain Injury.International journal of molecular sciences · 2024Review
- The clinical and genomic features of seizures in meningiomas.Neuro-oncology advances · 2023Article
- Aquaporin-5 Dynamic Regulation.International journal of molecular sciences · 2023Review
- Choroid Plexus Aquaporins in CSF Homeostasis and the Glymphatic System: Their Relevance for Alzheimer's Disease.International journal of molecular sciences · 2023Review
- Study of Association of Various Psychiatric Disorders in Brain Tumors.Asian journal of neurosurgery · 2022Article
- Review
- Epidural Hematoma: The Outcome of Glucocorticoids' Complementary Use to Surgical Treatment.Cureus · 2022Article
- Efficacy of Bevacizumab in High-Grade Meningiomas: A Retrospective Clinical Study.Neuropsychiatric disease and treatment · 2022Article
- Medical and Neurological Management of Brain Tumor Complications.Current neurology and neuroscience reports · 2021Review
- Incidence and type of brain herniation associated with intracranial meningioma in dogs and cats.The Journal of veterinary medical science · 2021Article
- Peritumoral edema correlates with mutational burden in meningiomas.Neuroradiology · 2021Article
- Association between tumor size and peritumoral brain edema in patients with convexity and parasagittal meningiomas.PloS one · 2021Article
- Article
- Pathogenesis of peri-tumoral edema in intracranial meningiomas.Neurosurgical review · 2019Review
- Aquaporin 5 expression correlates with tumor multiplicity and vascular invasion in hepatocellular carcinoma.International journal of clinical and experimental pathology · 2019Article
- Aquaporins in Brain Edema and Neuropathological Conditions.International journal of molecular sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporins (AQP) are a growing family of water-channel proteins, numbering 13 to date. Recent studies have reported AQP1 and AQP4 to be involved in the development and resorption of brain edemas of different origin. Other AQPs have also been detected in brain tissue, but their impact on brain edema remains to be shown. To evaluate a possible role of AQP5 in brain edema, we investigated the association of AQP5 expression and the functional AQP5 promoter polymorphism A(-1364)C with occurrence and intensity of peritumoral edema in meningioma patients. Peritumoral edema was classified in three degrees based on preoperative imaging in 89 meningioma patients treated at the University Hospital Essen between 2003 and 2006. AQP5 expression was assessed immunohistochemically in tumor tissue obtained during neurosurgical tumor resection. Genotypes of the A(-1364)C polymorphism were determined using the "slowdown" polymerase chain reaction. Higher levels of AQP5 expression were significantly correlated with the AQP5-1364 AA genotype (P = 0.02). AQP5 expression was positively correlated with edema (P = 0.04). AQP5 genotypes were not significantly associated with the occurrence, but with the intensity of peritumoral brain edema (P = 0.04). In our cohort, 40 % of patients with grade I, 66.7 % with grade II, and 76.5 % with grade III edema possessed at least one A allele. Development and intensity of peritumoral edema in meningiomas are associated with AQP5 expression. The intensity of edema correlates with the AQP5 A(-1364)C genotype. This suggests AQP5 as an interesting new candidate involved in peritumoral brain edema in meningioma patients.
Indexed as
Identifiers
23392848What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.