ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Parallel evolution of serotonergic neuromodulation underlies independent evolution of rhythmic motor behavior.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 50 citations in OpenAlex.
- Neural evolution of complex motor behaviors: insights from Drosophila courtship song.Current opinion in neurobiology · 2025Review
- Changes in the cellular makeup of motor patterning circuits drive courtship song evolution in Drosophila.Current biology : CB · 2024Article
- Cellular-resolution gene expression mapping reveals organization in the head ganglia of the gastropod, Berghia stephanieae.The Journal of comparative neurology · 2024Article
- Neuromodulation and the toolkit for behavioural evolution: can ecdysis shed light on an old problem?The FEBS journal · 2024Review
- Changes in the cellular makeup of motor patterning circuits drive courtship song evolution inbioRxiv : the preprint server for biology · 2024Article
- Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy.Brain : a journal of neurology · 2023Article
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- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- The Consistency of Gastropod Identified Neurons Distinguishes Intra-Individual Plasticity From Inter-Individual Variability in Neural Circuits.Frontiers in behavioral neuroscience · 2022Review
- The Wiring Logic of an Identified Serotonergic Neuron That Spans Sensory Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Similarities and differences in circuit responses to applied GlyJournal of neurophysiology · 2019Article
- Single neuron serotonin receptor subtype gene expression correlates with behaviour within and across three molluscan species.Proceedings. Biological sciences · 2018Article
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- Article
- Generative rules of Drosophila locomotor behavior as a candidate homology across phyla.Scientific reports · 2016Article
- Evolution of central pattern generators and rhythmic behaviours.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Identification of genes related to learning and memory in the brain transcriptome of the mollusc, Hermissenda crassicornis.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Phylogenetic and individual variation in gastropod central pattern generators.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
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- Frank Beach Award Winner: Steroids as neuromodulators of brain circuits and behavior.Hormones and behavior · 2014Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromodulation can dynamically alter neuronal and synaptic properties, thereby changing the behavioral output of a neural circuit. It is therefore conceivable that natural selection might act upon neuromodulation as a mechanism for sculpting the behavioral repertoire of a species. Here we report that the presence of neuromodulation is correlated with the production of a behavior that most likely evolved independently in two species: Tritonia diomedea and Pleurobranchaea californica (Mollusca, Gastropoda, Opisthobranchia, Nudipleura). Individuals of both species exhibit escape swimming behaviors consisting of repeated dorsal-ventral whole-body flexions. The central pattern generator (CPG) circuits underlying these behaviors contain homologous identified neurons: DSI and C2 in Tritonia and As and A1 in Pleurobranchaea. Homologs of these neurons also can be found in Hermissenda crassicornis where they are named CPT and C2, respectively. However, members of this species do not exhibit an analogous swimming behavior. In Tritonia and Pleurobranchaea, but not in Hermissenda, the serotonergic DSI homologs modulated the strength of synapses made by C2 homologs. Furthermore, the serotonin receptor antagonist methysergide blocked this neuromodulation and the swimming behavior. Additionally, in Pleurobranchaea, the robustness of swimming correlated with the extent of the synaptic modulation. Finally, injection of serotonin induced the swimming behavior in Tritonia and Pleurobranchaea, but not in Hermissenda. This suggests that the analogous swimming behaviors of Tritonia and Pleurobranchaea share a common dependence on serotonergic neuromodulation. Thus, neuromodulation may provide a mechanism that enables species to acquire analogous behaviors independently using homologous neural circuit components.
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