ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Novel higher-order epigenetic regulation of the Bdnf gene upon seizures.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
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- Epigenetic regulatory layers in the 3D nucleus.Molecular cell · 2024Review
- Seizure enhances SUMOylation and zinc-finger transcriptional repression in neuronal nuclei.iScience · 2023Article
- Modulation of chromatin architecture influences the neuronal nucleus through activity-regulated gene expression.Biochemical Society transactions · 2023Review
- Embryonic Stem Cell-Derived Neurons as a Model System for Epigenome Maturation during Development.Genes · 2023Article
- Therapeutic role of growth factors in treating diabetic wound.World journal of diabetes · 2023Review
- A novel intergenic enhancer that regulatesiScience · 2023Article
- Nuclear Architecture in the Nervous System.Results and problems in cell differentiation · 2022Review
- Anti-Epileptic Effect of Crocin on Experimental Temporal Lobe Epilepsy in Mice.Frontiers in pharmacology · 2022Article
- Article
- Activity-Dependent Gene Expression in Neurons.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Long Noncoding RNAs-Crucial Players Organizing the Landscape of the Neuronal Nucleus.International journal of molecular sciences · 2021Review
- PartSeg: a tool for quantitative feature extraction from 3D microscopy images for dummies.BMC bioinformatics · 2021Article
- SATB2-LEMD2 interaction links nuclear shape plasticity to regulation of cognition-related genes.The EMBO journal · 2021Article
- The Role of Brain-Derived Neurotrophic Factor in Epileptogenesis: an Update.Frontiers in pharmacology · 2021Review
- Article
- Neurobiological functions of transcriptional enhancers.Nature neuroscience · 2020Review
- Hippocampal stimulation promotes intracellular Tip60 dynamics with concomitant genome reorganization and synaptic gene activation.Molecular and cellular neurosciences · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies in cultured cells have demonstrated the existence of higher-order epigenetic mechanisms, determining the relationship between expression of the gene and its position within the cell nucleus. It is unknown, whether such mechanisms operate in postmitotic, highly differentiated cell types, such as neurons in vivo. Accordingly, we examined whether the intranuclear positions of Bdnf and Trkb genes, encoding the major neurotrophin and its receptor respectively, change as a result of neuronal activity, and what functional consequences such movements may have. In a rat model of massive neuronal activation upon kainate-induced seizures we found that elevated neuronal expression of Bdnf is associated with its detachment from the nuclear lamina, and translocation toward the nucleus center. In contrast, the position of stably expressed Trkb remains unchanged after seizures. Our study demonstrates that activation-dependent architectural remodeling of the neuronal cell nucleus in vivo contributes to activity-dependent changes in gene expression in the brain.
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