ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Fast computations in cortical ensembles require rapid initiation of action potentials.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers.Pflugers Archiv : European journal of physiology · 2024Pooled it
- Enhanced information processing in the human neocortex: cellular mechanisms and translational perspectives.Frontiers in synaptic neuroscience · 2026Review
- Biophysical and computational insights from modeling human cortical pyramidal neurons.Frontiers in neuroscience · 2025Review
- Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability.Gene therapy · 2024Article
- Variation and convergence in the morpho-functional properties of the mammalian neocortex.Frontiers in systems neuroscience · 2024Review
- Genes associated with cognitive ability and HAR show overlapping expression patterns in human cortical neuron types.Nature communications · 2023Article
- Article
- Mechanisms of Dominant Electrophysiological Features of Four Subtypes of Layer 1 Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Physiological noise facilitates multiplexed coding of vibrotactile-like signals in somatosensory cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Ultrafast population coding and axo-somatic compartmentalization.PLoS computational biology · 2022Article
- New methods for quantifying rapidity of action potential onset differentiate neuron types.PloS one · 2021Article
- The location of the axon initial segment affects the bandwidth of spike initiation dynamics.PLoS computational biology · 2020Article
- Homogeneous and Narrow Bandwidth of Spike Initiation in Rat L1 Cortical Interneurons.Frontiers in cellular neuroscience · 2020Article
- Dynamic Gain Analysis Reveals Encoding Deficiencies in Cortical Neurons That Recover from Hypoxia-Induced Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Correlation Transfer by Layer 5 Cortical Neurons Under Recreated Synaptic InputsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Review
- Article
- Article
- An axon initial segment is required for temporal precision in action potential encoding by neuronal populations.Science advances · 2018Article
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Authors and funding
4 authors.
Funding
Abstract
The abilities of neuronal populations to encode rapidly varying stimuli and respond quickly to abrupt input changes are crucial for basic neuronal computations, such as coincidence detection, grouping by synchrony, and spike-timing-dependent plasticity, as well as for the processing speed of neuronal networks. Theoretical analyses have linked these abilities to the fast-onset dynamics of action potentials (APs). Using a combination of whole-cell recordings from rat neocortical neurons and computer simulations, we provide the first experimental evidence for this conjecture and prove its validity for the case of distal AP initiation in the axon initial segment (AIS), typical for cortical neurons. Neocortical neurons with fast-onset APs in the soma can phase-lock their population firing to signal frequencies up to ∼300-400 Hz and respond within 1-2 ms to subtle changes of input current. The ability to encode high frequencies and response speed were dramatically reduced when AP onset was slowed by experimental manipulations or was intrinsically slow due to immature AP generation mechanisms. Multicompartment conductance-based models reproducing the initiation of spikes in the AIS could encode high frequencies only if AP onset was fast at the initiation site (e.g., attributable to cooperative gating of a fraction of sodium channels) but not when fast onset of somatic AP was produced solely by backpropagation. We conclude that fast-onset dynamics is a genuine property of cortical AP generators. It enables fast computations in cortical circuits that are rich in recurrent connections both within each region and across the hierarchy of areas.
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