Evidence map›Paper›PMID 23392464›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2013

Nevirapine inhibits the anti-HIV activity of CD8+ cells.

Lianxing Liu, Lin Wang, Liusheng Huang, Vincent Siu, Fernando Teque, Francesca T Aweeka, Jay A Levy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lianxing LiuDivision of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-1270, USA.
Lin Wang
Liusheng Huang
Vincent Siu
Fernando Teque
Francesca T Aweeka
Jay A Levy
University of California, San Francisco · US

Funding

Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6M
Role of Innate Immunity in Controlling HIV InfectionR01AI056992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVY, JAY A · 2003 to 2010
$4.2M
Role of Innate Immunity in Controlling HIV InfectionR56AI056992 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEVY, JAY A · 2007 to 2007
$231k
NIAID NIH HHS AI-056992NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI056992NIAID NIH HHS R56 AI056992
6 · The paper itself

Abstract

Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8(+) cells and thus could influence the effectiveness of antiretroviral therapy.

Indexed as

Anti-HIV AgentsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCells, CulturedCoculture TechniquesHIV-1HIV InfectionsHIV SeropositivityHumansNevirapineRNA, ViralZidovudineAnti-HIV AgentsNevirapineRNA, ViralZidovudine

Identifiers

PMID23392464
PMCPMC3653990
OpenAlexW1997772711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.