Trial reportPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies2013
Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children.
Trial report in Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Micronutrient status during paediatric critical illness: A scoping review.Clinical nutrition (Edinburgh, Scotland) · 2020Article
- Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition.Redox biology · 2018Article
- Assessment of Micronutrient Status in Critically Ill Children: Challenges and Opportunities.Nutrients · 2017Review
- Safety and Dose Escalation Study of Intravenous Zinc Supplementation in Pediatric Critical Illness.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- Assessment of serum zinc, selenium, and prolactin concentrations in critically ill children.Pediatric health, medicine and therapeutics · 2016Review
- Low plasma selenium concentrations in critically ill children: the interaction effect between inflammation and selenium deficiency.Critical care (London, England) · 2014Observational
- Combined zinc supplementation with proinsulin C-peptide treatment decreases the inflammatory response and mortality in murine polymicrobial sepsis.Shock (Augusta, Ga.) · 2014Article
- Early response roles for prolactin cortisol and circulating and cellular levels of heat shock proteins 72 and 90α in severe sepsis and SIRS.BioMed research international · 2014Article
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Authors and funding
14 authors.
Funding
Abstract
objectivesTo describe serum concentrations of zinc, selenium, and prolactin in critically ill children within 72 hours of PICU admission, and to investigate relationships between these immunomodulators and lymphopenia.
designAn analysis of baseline data collected as part of the multicenter Critical Illness Stress Induced Immune Suppression (CRISIS) Prevention Trial.
settingPICUs affiliated with the Collaborative Pediatric Critical Care Research Network. PATIENTS: All children enrolled in the CRISIS Prevention Trial that had baseline serum samples available for analysis.
interventionsNone. MEASUREMENTS AND MAIN
resultsOf 293 critically ill children enrolled in the CRISIS Prevention Trial, 284 had baseline serum samples analyzed for prolactin concentration, 280 for zinc concentration, and 278 for selenium concentration within 72 hours of PICU admission. Lymphocyte counts were available for 235 children. Zinc levels ranged from nondetectable (< 0.1 μg/mL) to 2.87 μg/mL (mean 0.46 μg/mL and median 0.44 μg/mL) and were below the normal reference range for 235 (83.9%) children. Selenium levels ranged from 26 to 145 ng/mL (mean 75.4 ng/mL and median 74.5 ng/mL) and were below the normal range for 156 (56.1%) children. Prolactin levels ranged from nondetectable (< 1 ng/mL) to 88 ng/mL (mean 12.2 ng/mL and median 10 ng/mL). Hypoprolactinemia was present in 68 (23.9%) children. Lymphopenia was more likely in children with zinc levels below normal than those with zinc levels within or above the normal range (82 of 193 [42.5%] vs. 10 of 39 [25.6%], p = 0.0498). Neither selenium nor prolactin concentrations were associated with lymphopenia (p = 1.0 and p = 0.72, respectively).
conclusionsSerum concentrations of zinc, selenium, and prolactin are often low in critically ill children early after PICU admission. Low serum zinc levels are associated with lymphopenia, whereas low selenium and prolactin levels are not. The implications of these findings and the mechanisms by which they occur merit further study.
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