Evidence map›Paper›PMID 23392340›Full record

ArticleIEEE transactions on bio-medical engineering2013

Evaluation of optical coherence tomography for the measurement of the effects of activators and anticoagulants on the blood coagulation in vitro.

Xiangqun Xu, Jinhai Geng, Gangjun Liu, Zhongping Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Xiangqun XuDepartment of Chemistry, Zhejiang Sci-Tech University, Hangzhou 310018, China. xuxiangqun@zstu.edu.cn
Jinhai Geng
Gangjun Liu
Zhongping Chen
Zhejiang Sci-Tech University · CNBeckman Laser Institute and Medical Clinic · USUniversity of California, Irvine · US

Funding

WOUND MIGRATION FORCE MONITORINGP41RR001192 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYUBOVITSKY, JULIA · 1985 to 2011
$14.2M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2012 to 2017
$7.0M
Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid DynamicsR01HL105215 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ELGHOBASHI, SAID E. · 2010 to 2013
$3.7M
Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCTR01HL103764 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WONG, BRIAN · 2010 to 2014
$3.1M
Integrated multi-modality intravascular US/OCT imaging systemR01EB010090 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING · 2009 to 2012
$2.3M
Elastographic Imaging of the Retina/Choroid in Age-Related Macular DegenerationR01EY021529 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHEN, ZHONGPING, SILVERMAN, RONALD H · 2012 to 2015
$1.4M
Mechanisms of lens growth regulationR01EY021519 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI GONG, XIAOHUA · 2011 to 2014
$1.2M
NCRR NIH HHS P41 RR001192NEI NIH HHS EY-021519NEI NIH HHS R01 EY021519NEI NIH HHS R01 EY021529NHLBI NIH HHS HL-105215NHLBI NIH HHS R01 HL103764NHLBI NIH HHS R01 HL105215NIBIB NIH HHS EB-015890NIBIB NIH HHS EB-10090NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R01 EB010090
6 · The paper itself

Abstract

Optical properties of human blood during coagulation were studied using optical coherence tomography (OCT) and the parameter of clotting time derived from the 1/e light penetration depth (d(1/e)) versus time was developed in our previous work. In this study, in order to know if a new OCT test can characterize the blood-coagulation process under different treatments in vitro, the effects of two different activators (calcium ions and thrombin) and anticoagulants, i.e., acetylsalicylic acid (ASA, a well-known drug aspirin) and melagatran (a direct thrombin inhibitor), at various concentrations are evaluated. A swept-source OCT system with a 1300 nm center wavelength is used for detecting the blood-coagulation process in vitro under a static condition. A dynamic study of d1/e reveals a typical behavior due to coagulation induced by both calcium ions and thrombin, and the clotting time is concentration-dependent. Dose-dependent ASA and melagatran prolong the clotting times. ASA and melagatran have different effects on blood coagulation. As expected, melagatran is much more effective than ASA in anticoagulation by the OCT measurements. The OCT assay appears to be a simple method for the measurement of blood coagulation to assess the effects of activators and anticoagulants, which can be used for activator and anticoagulant screening.

Indexed as

AnimalsAnticoagulantsBloodBlood CellsBlood CoagulationBlood Coagulation TestsCoagulantsDrug Evaluation, PreclinicalImage Interpretation, Computer-AssistedReproducibility of ResultsSensitivity and SpecificitySwineTomography, Optical CoherenceAnticoagulantsCoagulants

Identifiers

PMID23392340
PMCPMC3888882
OpenAlexW2031350435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.