Evidence map›Paper›PMID 23392279›Full record

ReviewExercise and sport sciences reviews2013

Myofilament protein alterations promote physical disability in aging and disease.

Mark S Miller, Michael J Toth

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026
    Article
  6. Motor performance and aging in males and females.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025
    Review
  7. Article
  8. Article
  9. Cumulative effects of HThe Journal of physiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Current perspectives on obesity and skeletal muscle contractile function in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
    Article
  19. Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark S MillerDepartment of Molecular Physiology and Biophysics, University of Vermont, College of Medicine, Burlington, VT 05405, USA.
Michael J Toth

Funding

WEIGHT MAINTENANCE AND PSYCHOLOGICAL BENEFITS OF EXERCISEM01RR000109 · NCRR · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI DUMAS, JULIE A · 1985 to 2010
$24.3M
Muscle disuse and contractile dysfunction in the elderlyR01AG033547 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2010 to 2014
$1.9M
Skeletal muscle contractile dysfunction in heart failureR01HL077418 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI TOTH, MICHAEL J · 2006 to 2009
$1.5M
Single Skeletal Muscle Fiber Mechanics and Myosin Kinetics in Human AgingK01AG031303 · NIA · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI MILLER, MARK STUART · 2008 to 2012
$611k
NCRR NIH HHS M01 RR000109NCRR NIH HHS RR-000109NHLBI NIH HHS HL-077418NHLBI NIH HHS R01 HL077418NIA NIH HHS AG-031303NIA NIH HHS K01 AG031303NIA NIH HHS R01 AG033547
6 · The paper itself

Abstract

Skeletal muscle contractile function declines with age and age-associated diseases. Although muscle atrophy undoubtedly contributes to this decrease, recent findings suggest that reduced myofilament protein content and function also may participate. Based on these data, we propose that age- and disease-related alterations in myofilament proteins represent one molecular mechanism contributing to the development of physical disability.

Indexed as

AgingAnimalsHeart FailureHumansMuscle ProteinsMyofibrilsMuscle Proteins

Identifiers

PMID23392279
PMCPMC4171103

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.