ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2013
Sex differences in brain response to anticipated and experienced visceral pain in healthy subjects.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Altered resting-state brain activity in functional dyspepsia patients: a coordinate-based meta-analysis.Frontiers in neuroscience · 2023Pooled it
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- Brain-based measures of nociception during general anesthesia with remifentanil: A randomized controlled trial.PLoS medicine · 2022Trial
- Preliminary report: parasympathetic tone links to functional brain networks during the anticipation and experience of visceral pain.Scientific reports · 2018Trial
- Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report.PloS one · 2014Trial
- Nationwide attribute-based cross-classification reveals distinct risk patterns of major complications in ADPKD.Clinical and experimental nephrology · 2026Article
- Muscle-Nerve Signaling and Neurogenic Inflammation in Temporomandibular Disorders: Potential Contributions of Occlusal Interference and Other Peripheral Triggers.Dentistry journal · 2026Review
- Sex differences in resting-state hypothalamic connectivity and its relationship with negative emotion and behavior measures in young adults.Brain structure & function · 2026Article
- Temporal lobe dysfunction for comorbid depressive symptoms in postherpetic neuralgia patients.Brain communications · 2025Article
- Review
- Chemogenetic Modulation of Posterior Insula CaMKIIa Neurons Alters Pain and Thermoregulation.The journal of pain · 2024Article
- Differentiating between stress- and EPT-induced electrodermal activity during dental examination.Computers in biology and medicine · 2023Article
- Sex Differences between Medical Students in the Assessment of the Fear of COVID-19.International journal of environmental research and public health · 2022Article
- Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals.Nature communications · 2020Article
- Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.Journal of affective disorders · 2020Article
- A neuroimaging marker for predicting longitudinal changes in pain intensity of subacute back pain based on large-scale brain network interactions.Scientific reports · 2020Article
- Neural responses during acute mental stress are associated with angina pectoris.Journal of psychosomatic research · 2020Article
- Sex differences in insular functional connectivity in response to noxious visceral stimulation in rats.Brain research · 2019Article
- Understanding Neurogastroenterology From Neuroimaging Perspective: A Comprehensive Review of Functional and Structural Brain Imaging in Functional Gastrointestinal Disorders.Journal of neurogastroenterology and motility · 2018Review
- Altered brain and gut responses to corticotropin-releasing hormone (CRH) in patients with irritable bowel syndrome.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Women demonstrate higher pain sensitivity and prevalence of chronic visceral pain conditions such as functional gastrointestinal disorders than men. The role of sex differences in the brain processing of visceral pain is still unclear. In 16 male and 16 female healthy subjects we compared personality, anxiety levels, skin conductance response (SCR), and brain processing using functional MRI during anticipation and pain induced by esophageal distension at pain toleration level. There was no significant difference in personality scores, anxiety levels, SCR, and subjective ratings of pain between sexes. In group analysis, both men and women demonstrated a similar pattern of brain activation and deactivation during anticipation and pain consistent with previous reports. However, during anticipation women showed significantly greater activation in the cuneus, precuneus, and supplementary motor area (SMA) and stronger deactivation in the right amygdala and left parahippocampal gyrus, whereas men demonstrated greater activation in the cerebellum. During pain, women demonstrated greater activation in the midcingulate cortex, anterior insula, premotor cortex, and cerebellum and stronger deactivation in the caudate, whereas men showed increased activity in the SMA. The pattern of brain activity suggests that, during anticipation, women may demonstrate stronger limbic inhibition, which is considered to be a cognitive modulation strategy for impending painful stimulation. During pain, women significantly activate brain areas associated with the affective and motivation components of pain. These responses may underlie the sex differences that exist in pain conditions, whereby women may attribute more emotional importance to painful stimuli compared with men.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.