Trial reportChest2013
Effects of experimental sleep restriction on caloric intake and activity energy expenditure.
Trial report in Chest, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01334788 (Sleep Deprivation and Energy Balance), which is not on this map. Cited by 82 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sleep Deprivation and Energy Balance
Who cites it
82 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systematic review of the associations between prenatal sleep behaviours and components of energy balance for regulating weight gain.Journal of sleep research · 2023Pooled it
- The effects of partial sleep deprivation on energy balance: a systematic review and meta-analysis.European journal of clinical nutrition · 2017Pooled it
- A systematic review and meta-analysis of randomized controlled trials of the impact of sleep duration on adiposity and components of energy balance.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2015Pooled it
- Effects of sleep deprivation on food-related Pavlovian-instrumental transfer: a randomized crossover experiment.Scientific reports · 2024Trial
- Late, but Not Early, Night Sleep Loss Compromises Neuroendocrine Appetite Regulation and the Desire for Food.Nutrients · 2023Trial
- The Effects of Acute Sleep Curtailment on Salt Taste Measures and Relationships with Energy-Corrected Sodium Intake: A Randomized Cross-Over Trial with Methodology Validation.International journal of environmental research and public health · 2023Trial
- Effects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity.Journal of the American College of Cardiology · 2022Trial
- Effects of ad libitum food intake, insufficient sleep and weekend recovery sleep on energy balance.Sleep · 2021Trial
- Increased Hunger, Food Cravings, Food Reward, and Portion Size Selection after Sleep Curtailment in Women Without Obesity.Nutrients · 2019Trial
- Influence of sleep restriction on weight loss outcomes associated with caloric restriction.Sleep · 2018Trial
- Increased energy intake following sleep restriction in men and women: A one-size-fits-all conclusion?Obesity (Silver Spring, Md.) · 2017Trial
- Phenotypic Stability of Energy Balance Responses to Experimental Total Sleep Deprivation and Sleep Restriction in Healthy Adults.Nutrients · 2016Trial
- Effect of Six-Month Diet Intervention on Sleep among Overweight and Obese Men with Chronic Insomnia Symptoms: A Randomized Controlled Trial.Nutrients · 2016Trial
- Elevated ghrelin predicts food intake during experimental sleep restriction.Obesity (Silver Spring, Md.) · 2016Trial
- Experimental sleep restriction causes endothelial dysfunction in healthy humans.Journal of the American Heart Association · 2014Trial
- Sex and race differences in caloric intake during sleep restriction in healthy adults.The American journal of clinical nutrition · 2014Trial
- Does Sleep Curtailment Stimulate Appetite, Motivation to Eat and Dietary Intake in Humans? A Narrative Synthesis of Evidence and Considerations for Future Studies.Journal of sleep research · 2026Review
- Clock Gene Variants Are Associated with Energy and Macronutrient Intake in Early Childhood and Adulthood.Nutrients · 2026Article
- Examining the Role of Sleep in Body Weight Regulation and Implications for Obesity Treatment: A Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- A Narrative Review on Sleep and Eating Behavior.Current diabetes reports · 2025Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on byResponse.2013
Authors and funding
10 authors.
Funding
Abstract
backgroundEpidemiologic studies link short sleep duration to obesity and weight gain. Insufficient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.
methodsWe conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin.
resultsCaloric intake in the sleep-restricted group increased by +559 kcal/d (SD, 706 kcal/d, P=.006) and decreased in the control group by -118 kcal/d (SD, 386 kcal/d, P=.51) for a net change of +677 kcal/d (95% CI, 148-1,206 kcal/d; P=.014). Sleep restriction was not associated with changes in activity energy expenditure (P=.62). No change was seen in levels of leptin (P=.27) or ghrelin (P=.21).
conclusionsSleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.
trial registrationClinicalTrials.gov; No.: NCT01334788; URL: www.clinicaltrials.gov.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.