ArticleIntegrative biology : quantitative biosciences from nano to macro2013
Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes.
Article in Integrative biology : quantitative biosciences from nano to macro, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Leveraging Tunable Nanoparticle Surface Functionalization to Alter Cellular Migration.ACS nanoscience Au · 2024Article
- Microfluidic-Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Generation of stable advective-diffusive chemokine gradients in a three-dimensional hydrogel.AIP advances · 2022Article
- Simulating CXCR5 Dynamics in Complex Tissue Microenvironments.Frontiers in immunology · 2021Article
- Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors.Neoplasia (New York, N.Y.) · 2020Article
- Concepts of GPCR-controlled navigation in the immune system.Immunological reviews · 2019Review
- Modeling neutrophil migration in dynamic chemoattractant gradients: assessing the role of exosomes during signal relay.Molecular biology of the cell · 2017Article
- A Novel Computational Model Predicts Key Regulators of Chemokine Gradient Formation in Lymph Nodes and Site-Specific Roles for CCL19 and ACKR4.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Determining whether observed eukaryotic cell migration indicates chemotactic responsiveness or random chemokinetic motion.Journal of theoretical biology · 2017Article
- Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks.Scientific reports · 2017Article
- Analytical Prediction of the Spatiotemporal Distribution of Chemoattractants around Their Source: Theory and Application to Complement-Mediated Chemotaxis.Frontiers in immunology · 2017Article
- The Contribution of Chemokines and Migration to the Induction of Central Tolerance in the Thymus.Frontiers in immunology · 2015Review
- Article
- Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning.Acta biomaterialia · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Chemoattractants regulate diverse immunological, developmental, and pathological processes, but how cell migration patterns are shaped by attractant production in tissues remains incompletely understood. Using computational modeling and chemokine-releasing microspheres (CRMs), cell-sized attractant-releasing beads, we analyzed leukocyte migration in physiologic gradients of CCL21 or CCL19 produced by beads embedded in 3D collagen gels. Individual T-cells that migrated into contact with CRMs exhibited characteristic highly directional migration to attractant sources independent of their starting position in the gradient (and thus independent of initial gradient strength experienced) but the fraction of responding cells was highly sensitive to position in the gradient. These responses were consistent with modeling calculations assuming a threshold absolute difference in receptor occupancy across individual cells of ~10 receptors required to stimulate chemotaxis. In sustained gradients eliciting low receptor desensitization, attracted T-cells or dendritic cells swarmed around isolated CRMs for hours. With increasing CRM density, overlapping gradients and high attractant concentrations caused a transition from local swarming to transient "hopping" of cells bead to bead. Thus, diverse migration responses observed in vivo may be determined by chemoattractant source density and secretion rate, which govern receptor occupancy patterns in nearby cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.