ArticleThe Indian journal of medical research2012
Non-albicans Candida species in blood stream infections in a tertiary care hospital at New Delhi, India.
Article in The Indian journal of medical research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- Global prevalence and trends of fluconazole resistance in non-albicans Candida species: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Virulence determinants, antifungal resistance, and genotype-phenotype associations in Candida bloodstream isolates: a three-year surveillance study from Northern India.Scientific reports · 2026Article
- An update on clinically relevant, rare, and emergingClinical microbiology reviews · 2025Review
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- A Combination of β-Aescin and Newly Synthesized Alkylamidobetaines as Modern Components Eradicating the Biofilms of Multidrug-Resistant Clinical Strains ofInternational journal of molecular sciences · 2024Article
- The Antifungal Efficacy of Pure Garlic, Onion, and Lemon Extracts Against Candida albicans.Cureus · 2023Article
- Emerging threat of candida resistance among neonates at a teaching institute of Jharkhand.Journal of family medicine and primary care · 2023Article
- Review
- The Threat CalledJournal of fungi (Basel, Switzerland) · 2022Article
- Expression and Purification along with Evaluation of Serological Response and Diagnostic Potential of Recombinant Sap2 Protein fromJournal of fungi (Basel, Switzerland) · 2021Article
- Risk Factors and Outcomes of Non-Journal of fungi (Basel, Switzerland) · 2021Article
- Clinical Profile of Non-neutropenic Patients with Invasive Candidiasis: A Retrospective Study in a Tertiary Care Center.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Article
- Insights into the Multi-Azole Resistance Profile inJournal of fungi (Basel, Switzerland) · 2020Article
- Pediatric Blood Cultures and Antibiotic Resistance: An Overview.Indian journal of pediatrics · 2020Review
- Article
- The role of Lactobacillus species in the control of Candida via biotrophic interactions.Microbial cell (Graz, Austria) · 2019Review
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectivesDuring recent decades, there has been a change in the epidemiology of Candida infections, characterized by a progressive shift from a predominance of Candida albicans to non-albicans Candida species. This study was undertaken to analyze the change in the epidemiology of candidaemia and antifungal use at tertiary care hospital in New Delhi, India, over a period of 10 years.
methodsA retrospective review of candidaemia between 1999 and 2008 and antifungal use from 2000 to 2008 was performed at Sir Ganga Ram Hosptial, New Delhi. Initially (1999-2005), isolates were differentiated as C. albicans and non- albicans Candida species. Between 2006-2008, these were identified to the species level and antifungal susceptibility was performed.
resultsThe occurrence of candidaemia and total antifungal use increased significantly. Candidaemia due to non-albicans species increased and this was correlated with an increasing use of fluconazole. There was emergence and increased isolation of a novel species C. haemulonii with decreased susceptibility to both amphotericin B and azoles. Overall, sensitivities of 89.6, 90.9, 88.6, 68.8 and 54.3 per cent to amphotericin B, 5 flucytosine, voriconazole, fluconazole and itraconazole, respectively were observed. Cross-resistance or reduced susceptibility to both fluconazole (MIC >16 μg/ml) and voriconazole was observed in 11.3 per cent isolates. INTERPRETATION &
conclusionsThe study demonstrates a shift to non-albicans Candida species causing fungaemia and the emergence of amphotericin B and azole resistant novel species, C. haemulonii. Decreased susceptibility to fluconazole, as well as the threat of emergence of cross-resistance to voriconazole in the background of high azole consumption may limit the use of these agents as a presumptive therapy for Candida blood stream infections (BSI).
Indexed as
Identifiers
23391796PMC3612330W2104248167What OpenQuestion holds
Registered trials
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