ReviewEndocrinology and metabolism clinics of North America2013
Defective counterregulation and hypoglycemia unawareness in diabetes: mechanisms and emerging treatments.
Review in Endocrinology and metabolism clinics of North America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A Systematic Review of Neuroprotective Strategies in the Management of Hypoglycemia.International journal of molecular sciences · 2019Pooled it
- Mitigation of Rebound Hyperglycemia With Real-Time Continuous Glucose Monitoring Data and Predictive Alerts.Journal of diabetes science and technology · 2022Trial
- Role of intestinal glucagon-like peptide-1 in impaired counter-regulatory responses to hypoglycemia.World journal of diabetes · 2024Article
- A rare case report of reversible glucose counterregulation in an insulinoma patient with type 2 diabetes.Endocrine · 2024Article
- Role of the Adrenal Medulla in Hypoglycaemia-Associated Autonomic Failure-A Diabetic Perspective.Metabolites · 2024Review
- Evaluating the effectiveness of a novel somatostatin receptor 2 antagonist, ZT-01, for hypoglycemia prevention in a rodent model of type 2 diabetes.Frontiers in pharmacology · 2024Article
- Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid.Journal of visualized experiments : JoVE · 2023Article
- Severe Hypoglycemia and the Use of Glucagon Rescue Agents: An Observational Survey in Adults With Type 1 Diabetes.Clinical diabetes : a publication of the American Diabetes Association · 2023Article
- Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice.Frontiers in endocrinology · 2023Article
- Hypoglycaemia events with iGlarLixi versus premix biphasic insulin aspart 30 (BIAsp 30) in people with type 2 diabetes advancing from basal insulin: An analysis of the SoliMix trial.Diabetes, obesity & metabolism · 2022Article
- Effect of Education on Impaired Hypoglycemia Awareness and Glycemic Variability in Children and Adolescents with Type 1 Diabetes MellitusJournal of clinical research in pediatric endocrinology · 2019Article
- Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia.Diabetes · 2017Article
- Practical Approaches to Diagnosing, Treating and Preventing Hypoglycemia in Diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2017Review
- Standardizing Clinically Meaningful Outcome Measures Beyond HbADiabetes care · 2017Review
- Glargine and degludec: Solution behaviour of higher dose synthetic insulins.Scientific reports · 2017Article
- [A case of insulinoma complicated with secondary adrenal insufficiency].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2017Article
- Current therapeutic approaches in the management of hyperglycemia in chronic renal disease.Reviews in endocrine & metabolic disorders · 2017Review
- Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Leptin acts in the brain to influence hypoglycemic counterregulation: disparate effects of acute and recurrent hypoglycemia on glucagon release.American journal of physiology. Endocrinology and metabolism · 2015Article
- Hypothalamic-Pituitary-Adrenal Axis Programming after Recurrent Hypoglycemia during Development.Journal of clinical medicine · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
For people with diabetes, hypoglycemia remains the limiting factor in achieving glycemic control. This article reviews recent advances in how the brain senses and responds to hypoglycemia. Novel mechanisms by which individuals with insulin-treated diabetes develop hypoglycemia unawareness and impaired counterregulatory responses are outlined. Prevention strategies for reducing the incidence of hypoglycemia are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.