Evidence map›Paper›PMID 23391167›Full record

Trial reportThe Journal of surgical research2013

Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging.

Boudewijn E Schaafsma, Floris P R Verbeek, Joost R van der Vorst, Merlijn Hutteman, Peter J K Kuppen, John V Frangioni, Cornelis J H van de Velde, Alexander L Vahrmeijer

Erratum issuedOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of surgical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. [Fluorescence-guided detection of lymph node metastases of gastrointestinal tumors].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2019
    Review
  10. Management of nodal disease from colon cancer in the laparoscopic era.International journal of colorectal disease · 2015
    Review
  11. Review
  12. Review
  13. Image-guided cancer surgery using near-infrared fluorescence.Nature reviews. Clinical oncology · 2013
    Review
4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Boudewijn E SchaafsmaDepartment of Surgery, University Medical Center, Leiden, The Netherlands.
Floris P R Verbeek
Joost R van der Vorst
Merlijn Hutteman
Peter J K Kuppen
John V Frangioni
Cornelis J H van de Velde
Alexander L Vahrmeijer
Leiden University Medical Center · NLBeth Israel Deaconess Medical Center · US

Funding

Intraoperative Near-Infrared Fluorescence ImagingR01CA115296 · NCI · CURADEL, LLC · PI FRANGIONI, JOHN V · 2005 to 2014
$13.9M
NIR Fluorescent SLN Mapping for Breast CancerR21CA130297 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRANGIONI, JOHN V · 2008 to 2009
$765k
NCI NIH HHS R01 CA115296NCI NIH HHS R01-CA-115296NCI NIH HHS R21 CA130297NCI NIH HHS R21-CA-130297
6 · The paper itself

Abstract

backgroundThe sentinel lymph node procedure has been proposed to improve nodal staging in colon cancer patients. The aim of this study was to assess the added value of near-infrared (NIR) fluorescence imaging to conventional blue dye staining for ex vivo sentinel lymph node mapping. MATERIALS AND

methodsWe included 22 consecutive patients undergoing surgery for colon cancer. After tumor resection, we submucosally injected a premixed cocktail of the near-infrared lymphatic tracer HSA800 and blue dye around the tumor for detection of sentinel lymph nodes. We used the Mini-FLARE imaging system for fluorescence imaging.

resultsIn 95% of patients, we identified at least one sentinel lymph node. Overall, a total of 77 sentinel lymph nodes were identified, 77 of which were fluorescent (100%) and 70 of which were blue (91%). Sentinel lymph nodes that were located deeper in the mesenteric fat could easily be located by NIR fluorescence. In four of five patients with lymph node metastases, tumor cells were present in at least one of the sentinel lymph nodes.

conclusionsThis study shows the successful use and added value of the NIR fluorescence tracer HSA800 to conventional blue dye for the ex vivo sentinel lymph node procedure in colon cancer.

Indexed as

BenzenesulfonatesFluorescent DyesIndolesSentinel Lymph Node BiopsyAdultAgedAged, 80 and overColonColonic NeoplasmsFeasibility StudiesFemaleHumansMaleMiddle AgedNeoplasm StagingOptical ImagingBenzenesulfonatesFluorescent DyesIndolesIRDye 800CW

Identifiers

PMID23391167
PMCPMC3824623
OpenAlexW2037363324

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.