Evidence map›Paper›PMID 23390944›Full record

ReviewExpert review of clinical immunology2013

Mast cells: multitalented facilitators of protection against bacterial pathogens.

Nikita H Trivedi, M Neal Guentzel, Annette R Rodriguez, Jieh-Juen Yu, Thomas G Forsthuber, Bernard P Arulanandam

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. p16Immunity & ageing : I & A · 2024
    Article
  5. Article
  6. Mechanisms of Mast Cell Activation in Severe Asthma: Beyond IgE.American journal of respiratory and critical care medicine · 2022
    Article
  7. Uncovering the Mast Cell Response toFrontiers in immunology · 2022
    Review
  8. Dermal Extracellular Matrix-Derived Hydrogels as anTissue engineering. Part A · 2021
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Mast cells are critical for controlling the bacterial burden and the healing of infected wounds.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  14. Mast cell activators as novel immune regulators.Current opinion in pharmacology · 2018
    Review
  15. Stimulation of nAchRα7 Receptor Inhibits TNF Synthesis and Secretion in Response to LPS Treatment of Mast Cells by Targeting ERK1/2 and TACE Activation.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2018
    Article
  16. Mast Cells Are Activated byFrontiers in immunology · 2018
    Article
  17. Review
  18. Article
  19. Cathelicidin impact on inflammatory cells.Central-European journal of immunology · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nikita H TrivediSouth Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX 78249, USA.
M Neal Guentzel
Annette R Rodriguez
Jieh-Juen Yu
Thomas G Forsthuber
Bernard P Arulanandam
Texas Center for Infectious Disease · USThe University of Texas at San Antonio · US

Funding

STRUCTURAL VISUALIZATION IN BIOINFORMATICSG12RR013646 · NCRR · UNIVERSITY OF TEXAS SAN ANTONIO · PI JOSE-YACAMAN, MIGUEL · 1998 to 2011
$19.6M
RCMI Center for Interdiscplinary Health Research CIHRG12MD007591 · NIMHD · UNIVERSITY OF TEXAS SAN ANTONIO · PI PERRY, GEORGE · 2012 to 2016
$10.4M
NCRR NIH HHS G12 RR013646NIMHD NIH HHS G12 MD007591NIMHD NIH HHS G12MD007591
6 · The paper itself

Abstract

Mast cells are crucial effector cells evoking immune responses against bacterial pathogens. The positioning of mast cells at the host-environment interface, and the multitude of pathogen-recognition receptors and preformed mediator granules make these cells potentially the earliest to respond to an invading pathogen. In this review, the authors summarize the receptors used by mast cells to recognize invading bacteria and discuss the function of immune mediators released by mast cells in control of bacterial infection. The interaction of mast cells with other immune cells, including macrophages, dendritic cells and T cells, to induce protective immunity is highlighted. The authors also discuss mast cell-based vaccine strategies and the potential application in control of bacterial disease.

Indexed as

Bacterial VaccinesImmunotherapy, AdoptiveAnimalsBacterial InfectionsCell CommunicationCell DegranulationHost-Pathogen InteractionsHumansImmunity, ActiveMast CellsReceptors, Pattern RecognitionBacterial VaccinesReceptors, Pattern Recognition

Identifiers

PMID23390944
PMCPMC4070289
OpenAlexW2057121443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.