ArticleAtherosclerosis2013
Sex-influenced association of nonalcoholic fatty liver disease with coronary heart disease.
Article in Atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Risk factors of coronary artery disease in metabolic-associated fatty liver disease: a single center cross-sectional study.Frontiers in cardiovascular medicine · 2026Article
- Association of liver related biomarkers with incident cardiovascular disease and all-cause mortality in the Hispanic community health study/study of Latinos (HCHS/SOL), a population-based cohort study.BMC gastroenterology · 2025Article
- Association Between Noninvasive Liver Fibrosis Scores and Heart Failure in a General Population.Journal of the American Heart Association · 2024Article
- Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma: A Literature Review.Cancers · 2024Review
- Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors.International journal of molecular sciences · 2023Review
- Gender-specific effects of oxidative balance score on the prevalence of diabetes in the US population from NHANES.Frontiers in endocrinology · 2023Article
- Serum alanine aminotransferase activity and risk factors for cardiovascular disease in a Caucasian population: the Tromsø study.BMC cardiovascular disorders · 2021Article
- COVID-19 and Sex Differences: Mechanisms and Biomarkers.Mayo Clinic proceedings · 2020Review
- Marked Influence of Adiposity on Laboratory Biomarkers in a Healthy Cohort of Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2020Article
- TRIB1 rs17321515 gene polymorphism increases the risk of coronary heart disease in general population and non-alcoholic fatty liver disease patients in Chinese Han population.Lipids in health and disease · 2019Article
- Sex differences in cardiac and renal responses to a high salt diet in Sprague-Dawley rats.Heliyon · 2019Article
- Cardiovascular Risk in Fatty Liver Disease: The Liver-Heart Axis-Literature Review.Frontiers in medicine · 2019Review
- Alanine Aminotransferase and Body Composition in Obese Men and Women.Disease markers · 2019Article
- Improved Diet Quality Associates With Reduction in Liver Fat, Particularly in Individuals With High Genetic Risk Scores for Nonalcoholic Fatty Liver Disease.Gastroenterology · 2018Article
- NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk.Advances in therapy · 2017Review
- Bi-directional analysis between fatty liver and cardiovascular disease risk factors.Journal of hepatology · 2017Article
- Sex influenced association of directly measured insulin sensitivity and serum transaminase levels: Why alanine aminotransferase only predicts cardiovascular risk in men?Cardiovascular diabetology · 2015Article
- Nonalcoholic fatty liver disease and cardiovascular disease.World journal of gastroenterology · 2014Review
- Relationship between retinal vascular caliber and coronary artery disease in patients with non-alcoholic fatty liver disease (NAFLD).International journal of environmental research and public health · 2013Observational
- Whole blood gene expression profiles in insulin resistant Latinos with the metabolic syndrome.PloS one · 2013Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveThis study investigated whether nonalcoholic fatty liver disease (NAFLD) predicts prevalent coronary heart disease (CHD).
methodsEpidemiologic studies have used various definitions for NAFLD. Here, we considered both liver fat burden measured by CT (FL) and the non-specific measure of hepatic inflammation -alanine aminotransferase (ALT). The association of FL and ALT with CHD (self report of coronary bypass, myocardial infarction, or percutaneous transluminal coronary angioplasty) was investigated in 2756 European-American participants of the Family Heart Study.
resultsFL (p = 0.0084) and ALT (≥40 U/L, p = 0.014) were each individually associated with prevalent CHD. However, when accounting for traditional metabolic risk factors in a multivariate model FL had no predictive value for CHD in either men or women; whereas ALT was a significant predictor of CHD in men, and the association strengthened among non-diabetic men. In non-diabetic women, neither FL nor ALT was associated with CHD.
conclusionsALT (≥40 U/L) was a predictor of prevalent CHD in men but not in women, while CT measured FL was not significant in either sex. The failure to account for traditional risk factors, heterogeneity by sex, and varying definitions of NAFLD may account for some of the conflicting evidence in the literature regarding the association between NAFLD and coronary disease.
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