ArticleeLife2013
Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 91 citations in OpenAlex.
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- Deciphering the regulatory mechanism of neural behavioral decisions through biogenic amine-mediated modulation of neural circuits inFrontiers in systems neuroscience · 2026Review
- Context-dependent serotonin signaling links dietary quality to foraging decisions.Nature communications · 2025Article
- Methionine cycle in C. elegans serotonergic neurons regulates diet-dependent behaviour and longevity through neuron-gut signaling.Nature communications · 2025Article
- Serotonergic modulation of swallowing in a complete fly vagus nerve connectome.Current biology : CB · 2024Article
- Fantastic beasts and how to study them: rethinking experimental animal behavior.The Journal of experimental biology · 2024Article
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- The nematode wormeLife · 2023Article
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- The role of food odor in invertebrate foraging.Genes, brain, and behavior · 2022Review
- Modulation of sensory perception by hydrogen peroxide enables Caenorhabditis elegans to find a niche that provides both food and protection from hydrogen peroxide.PLoS pathogens · 2021Article
- Risperidone induced alterations in feeding and locomotion behavior ofCurrent research in toxicology · 2021Article
- Behavioral States.Genetics · 2020Review
- Feeding, hunger, satiety and serotonin in invertebrates.Proceedings. Biological sciences · 2020Article
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- Global Transcriptome Changes That Accompany Alterations in Serotonin Levels inG3 (Bethesda, Md.) · 2020Article
- A Comprehensive Understanding of Dietary Effects on C. elegans Physiology.Current medical science · 2019Review
- Reciprocal modulation of 5-HT and octopamine regulates pumping via feedforward and feedback circuits inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- IsGenes & nutrition · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Familiarity discrimination has a significant impact on the pattern of food intake across species. However, the mechanism by which the recognition memory controls feeding is unclear. Here, we show that the nematode Caenorhabditis elegans forms a memory of particular foods after experience and displays behavioral plasticity, increasing the feeding response when they subsequently recognize the familiar food. We found that recognition of familiar food activates the pair of ADF chemosensory neurons, which subsequently increase serotonin release. The released serotonin activates the feeding response mainly by acting humorally and directly activates SER-7, a type 7 serotonin receptor, in MC motor neurons in the feeding organ. Our data suggest that worms sense the taste and/or smell of novel bacteria, which overrides the stimulatory effect of familiar bacteria on feeding by suppressing the activity of ADF or its upstream neurons. Our study provides insight into the mechanism by which familiarity discrimination alters behavior.DOI:http://dx.doi.org/10.7554/eLife.00329.001.
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Registered trials
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