ArticleeLife2013
Hierarchical organization of context in the hippocampal episodic code.
Article in eLife, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Adaptation of hippocampal spatial and contextual representations to task structure.Science advances · 2025Article
- Working memory features are embedded in hippocampal place fields.Cell reports · 2024Article
- Emergence of the Hippocampus as a Vector for Goal-Directed Spatial Navigation.Advances in neurobiology · 2024Review
- Contextual memory engrams, and the neuromodulatory influence of the locus coeruleus.Frontiers in molecular neuroscience · 2024Review
- How our understanding of memory replay evolves.Journal of neurophysiology · 2023Review
- Review
- A Review of Neurologgers for Extracellular Recording of Neuronal Activity in the Brain of Freely Behaving Wild Animals.Micromachines · 2022Review
- Complementary roles of differential medial entorhinal cortex inputs to the hippocampus for the formation and integration of temporal and contextual memory (Systems Neuroscience).The European journal of neuroscience · 2021Review
- Genetic Depletion of BDNF Impairs Extinction Learning of a Spatial Appetitive Task in the Presence or Absence of the Acquisition Context.Frontiers in behavioral neuroscience · 2021Article
- The mysteries of remote memory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Deciphering Neural Codes of Memory during Sleep.Trends in neurosciences · 2017Review
- Experience-Related Changes in Place Cell Responses to New Sensory Configuration That Does Not Occur in the Natural Environment in the Rat Hippocampus.Frontiers in pharmacology · 2017Article
- Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders.The journal of physiological sciences : JPS · 2016Review
- Article
- Episodic-like memory trace in awake replay of hippocampal place cell activity sequences.eLife · 2015Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampal system appears to be critically important in establishing episodic memory of both internal and external events within contexts as well as spatial memory, which enables flexible spatial navigation. However, the neuronal substrates that function across different memories in the hippocampal system are poorly understood. I monitored large-scale activity patterns of hippocampal neuronal ensembles in rats performing a novel, continuous task that combined one visually guided and two memory-guided types of navigations in a constant environment. I found that the activity patterns of the hippocampal ensemble represent spatiotemporal contexts (journeys) constructed by temporally ordered past, present and expected future places in tandem with visually or mnemonically guided non-spatial contexts (task-demands) to form episodes. This finding therefore suggests that the hierarchical organization of contexts based on pattern separation and completion enables the hippocampus to play a dual role in spatial navigation and recall of episodic memory.DOI:http://dx.doi.org/10.7554/eLife.00321.001.
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