ArticlePloS one2013
rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Finding tau rhythms in EEG: An independent component analysis approach.Human brain mapping · 2024Article
- Cortical Reorganization after Limb Loss: Bridging the Gap between Basic Science and Clinical Recovery.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Effect of sound therapy on whole scalp oscillatory brain activity and distress in chronic tinnitus patients.Frontiers in neuroscience · 2023Article
- Higher Peripheral Inflammation Is Associated With Lower Orbitofrontal Gamma Power in Chronic Tinnitus.Frontiers in behavioral neuroscience · 2022Article
- Cerebellum and Neurorehabilitation in Emotion with a Focus on Neuromodulation.Advances in experimental medicine and biology · 2022Article
- Decoding Object-Based Auditory Attention from Source-Reconstructed MEG Alpha Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- EEG power spectral dynamics associated with listening in adverse conditions.Psychophysiology · 2021Article
- Heading for Personalized rTMS in Tinnitus: Reliability of Individualized Stimulation Protocols in Behavioral and Electrophysiological Responses.Journal of personalized medicine · 2021Article
- A narrative review on non-invasive stimulation of the cerebellum in neurological diseases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment in Vestibular Schwannoma: A Pilot Study.Frontiers in neurology · 2021Article
- Short-Term Tinnitus Suppression With Electric-Field Guided rTMS for Individualizing rTMS Treatment: A Technical Feasibility Report.Frontiers in neurology · 2020Article
- Non-invasive Cerebellar Stimulation: Moving Towards Clinical Applications for Cerebellar and Extra-Cerebellar Disorders.Cerebellum (London, England) · 2018Article
- Pathophysiology of Subjective Tinnitus: Triggers and Maintenance.Frontiers in neuroscience · 2018Review
- Insights Into Auditory Cortex Dynamics From Non-invasive Brain Stimulation.Frontiers in neuroscience · 2018Review
- Targeting Heterogeneous Findings in Neuronal Oscillations in Tinnitus: Analyzing MEG Novices and Mental Health Comorbidities.Frontiers in psychology · 2018Article
- Pairing sound with vagus nerve stimulation modulates cortical synchrony and phase coherence in tinnitus: An exploratory retrospective study.Scientific reports · 2017Article
- Targeting the Cerebellum by Noninvasive Neurostimulation: a Review.Cerebellum (London, England) · 2017Review
- An Increase in Alpha Band Frequency in Resting State EEG after Electrical Stimulation of the Ear in Tinnitus Patients-A Pilot Study.Frontiers in neuroscience · 2016Article
- Tinnitus: perspectives from human neuroimaging.Nature reviews. Neuroscience · 2015Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients. This may be due to a lack of knowledge regarding how rTMS affects oscillatory activity in tinnitus sufferers and which modulations are associated with tinnitus relief. In the present study we examined the effects of five different stimulation protocols (including sham) by measuring tinnitus loudness and tinnitus-related brain activity with Magnetoencephalography before and after rTMS. Changes in oscillatory activity were analysed for the stimulated auditory cortex as well as for the entire brain regarding certain frequency bands of interest (delta, theta, alpha, gamma). In line with the literature the effects of rTMS on tinnitus loudness varied strongly across patients. This variability was also reflected in the rTMS effects on oscillatory activity. Importantly, strong reductions in tinnitus loudness were associated with increases in alpha power in the stimulated auditory cortex, while an unspecific decrease in gamma and alpha power, particularly in left frontal regions, was linked to an increase in tinnitus loudness. The identification of alpha power increase as main correlate for tinnitus reduction sheds further light on the pathophysiology of tinnitus. This will hopefully stimulate the development of more effective therapy approaches.
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