ArticleJournal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent2013
Amantadine: a review of use in child and adolescent psychiatry.
Article in Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Glutamatergic candidate genes in autism spectrum disorder: an overview.Journal of neural transmission (Vienna, Austria : 1996) · 2014Pooled it
- Potential antidepressant effect of amantadine: a review of preclinical studies and clinical trials.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Pooled it
- A potential strategy for improving offspring behavior in maternal immune activation: Amantadine-mediated suppression of neuroinflammation.Animal models and experimental medicine · 2025Article
- Review
- Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models.Research square · 2023Article
- Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.The international journal of biochemistry & cell biology · 2022Review
- Amantadine for the treatment of childhood and adolescent psychiatric symptoms.Proceedings (Baylor University. Medical Center) · 2021Article
- Mechanism and adverse effects of COVID-19 drugs: a basic review.International journal of physiology, pathophysiology and pharmacology · 2021Review
- Possibility of a New Indication for Amantadine in the Treatment of Bipolar Depression-Case Series Study.Pharmaceuticals (Basel, Switzerland) · 2020Article
- A pediatric neurobehavioral treatment challenge.eNeurologicalSci · 2020Article
- The Neurochemistry of Autism.Brain sciences · 2020Article
- Therapeutic Advances for Huntington's Disease.Brain sciences · 2020Review
- Associations Between Amantadine Usage, Gait, and Cognition in PSP: AFrontiers in neurology · 2020Article
- Article
- Perampanel but Not Amantadine Prevents Behavioral Alterations and Epileptogenesis in Pilocarpine Rat Model of Status Epilepticus.Molecular neurobiology · 2019Article
- New directions in therapeutics for Huntington disease.Future neurology · 2018Review
- The drug treatment of delayed ejaculation.Translational andrology and urology · 2016Review
- A selective review of glutamate pharmacological therapy in obsessive-compulsive and related disorders.Psychology research and behavior management · 2015Review
- Compounds with anti-influenza activity: present and future of strategies for the optimal treatment and management of influenza. Part I: Influenza life-cycle and currently available drugs.Journal of preventive medicine and hygiene · 2014Review
- The co-occurrence of autism and attention deficit hyperactivity disorder in children - what do we know?Frontiers in human neuroscience · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review published literature regarding the pharmacology and use of amantadine in child and adolescent psychiatry.
methodA LITERATURE SEARCH OF SEVERAL DATABASES (PUBMED, PSYCHINFO, CINAHL, MEDLINE, PSYCARTICLES, BIOMEDICAL REFERENCE COLLECTION AND ACADEMIS SEARCH COMPLETE) WAS CONDUCTED WITH THE SEARCH TERMS: 'amantadine' with limits: English language, Human trials, all child (aged 0-18 years). The search was later expanded to include 'Adults' and additional relevant articles were selected from reference lists.
resultsThe psychotropic effect of amantadine is related to its antagonism of the N-methyl-D-aspartate (NMDA) receptor. It decreases the toxic effects of the glutamatergic neurotransmitter system which plays an important role in many psychiatric disorders. Two randomized controlled trials (RCTs) of amantadine were identified in children and adolescents. One reported beneficial effects in controlling the symptoms of irritability and hyperactivity in autistic disorder and the other described a significant impact in attention deficit hyperactivity disorder (ADHD). Two open label studies also reported positive effects in ADHD. A pilot study in children with enuresis reported significant reduction in wetting frequency. Studies in adults, with relevance to children and adolescents, reported effectiveness in resistant depression, obsessive compulsive disorder and in counteracting side effects of some psychotropic medications. RCTs found in traumatic brain injury indicated a neuroprotective effect and effectiveness in controlling agitation and aggression. Amantadine is well tolerated in children and adolescents, with an acceptable side effect profile, and considered safe for long term use.
conclusionAmantadine shows potential for use as a safe alternative or as an augmenting agent for treating children with neuropsychiatric and various other disorders. Available data for such use, although promising, require further confirmation.
Indexed as
Identifiers
23390434PMC3565716What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.