ArticleBioinformation2013
Computational model for pathway reconstruction to unravel the evolutionary significance of melanin synthesis.
Article in Bioinformation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- On the Origin of Information Dynamics in Early Life.Life (Basel, Switzerland) · 2025Article
- Skin-Whitening Effect of a Callus Extract ofPlants (Basel, Switzerland) · 2023Article
- Effect of Melanization on Thallus Microstructure in the LichenJournal of fungi (Basel, Switzerland) · 2022Article
- Production and characterization of crude laccase from Irpex sp. JS7 that decolorizes synthetic and natural melanin.Folia microbiologica · 2021Article
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- Morphological and biological characterization of a light-colored mutant in the multicolored Asian lady beetle,Ecology and evolution · 2018Article
- A population of wheat multiple synthetic derivatives: an effective platform to explore, harness and utilize genetic diversity of Aegilops tauschii for wheat improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Isolation and identification of a gene encoding 4-hydroxyphenylpyruvate dioxygenase from the red-brown pigment-producing bacterium Alteromonas stellipolaris LMG 21856.Folia microbiologica · 2015Article
- Melanin-Like Pigment Synthesis by Soil Bacillus weihenstephanensis Isolates from Northeastern Poland.PloS one · 2015Article
- Insect prophenoloxidase: the view beyond immunity.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanogenesis is a complex multistep process of high molecular weight melanins production by hydroxylation and polymerization of polyphenols. Melanins have a wide range of applications other than being a sun - protection pigment. Melanogenesis pathway exists from prokaryotes to eukaryotes. It has evolved over years owing to the fact that the melanin pigment has different roles in diverse taxa of organisms. Melanin plays a pivotal role in the existence of certain bacteria and fungi whereas in higher organisms it is a measure of protection against the harmful radiation. We have done a detailed study on various pathways known for melanin synthesis across species. It was divulged that melanin production is not restricted to tyrosine but there are other secondary metabolites that synthesize melanin in lower organisms. Furthermore the phylogenetic study of these paths was done to understand their molecular and cellular development. It has revealed that the melanin synthesis paths have co-evolved in several groups of organisms. In this study, we also introduce a method for the comparative analysis of a metabolic pathway to study its evolution based on similarity between enzymatic reactions.
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