ArticleNeurology2013
Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia.
Article in Neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 203 citations in OpenAlex.
- Towards affordable biomarkers of frontotemporal dementia: A classification study via network's information sharing.Scientific reports · 2017Trial
- Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Network Connectivity Alterations across the MAPT Mutation Clinical Spectrum.Annals of neurology · 2023Article
- The New Zealand Genetic Frontotemporal Dementia Study (FTDGeNZ): a longitudinal study of pre-symptomatic biomarkers.Journal of the Royal Society of New Zealand · 2023Article
- Structural MRI predicts clinical progression in presymptomatic genetic frontotemporal dementia: findings from the GENetic Frontotemporal dementia Initiative cohort.Brain communications · 2023Article
- Altered Anterior Insular Metabolic Connectivity in Asymptomatic MAPT P301L Carriers.Journal of Alzheimer's disease : JAD · 2023Article
- Default Mode Network quantitative diffusion and resting-state functional magnetic resonance imaging correlates in sporadic Creutzfeldt-Jakob disease.Human brain mapping · 2022Article
- The CBI-R detects early behavioural impairment in genetic frontotemporal dementia.Annals of clinical and translational neurology · 2022Article
- Reconfigured metabolism brain network in asymptomatic microtubule-associated protein tau mutation carriers: a graph theoretical analysis.Alzheimer's research & therapy · 2022Article
- Right uncinate fasciculus supports socioemotional sensitivity in health and neurodegenerative disease.NeuroImage. Clinical · 2022Article
- The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort.Alzheimer's research & therapy · 2021Observational
- Brain volumetric deficits in MAPT mutation carriers: a multisite study.Annals of clinical and translational neurology · 2021Article
- Investigating Neuroimaging Correlates of Early Frailty in Patients With Behavioral Variant Frontotemporal Dementia: A MRI and FDG-PET Study.Frontiers in aging neuroscience · 2021Article
- Robust automated computational approach for classifying frontotemporal neurodegeneration: Multimodal/multicenter neuroimaging.Alzheimer's & dementia (Amsterdam, Netherlands) · 2019Article
- Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia.Neurobiology of aging · 2019Article
- Neuroimaging in aging and neurologic diseases.Handbook of clinical neurology · 2019Review
- Prodromal and Early bvFTD: Evaluating Clinical Features and Current Biomarkers.Frontiers in neuroscience · 2019Review
- Divergent patterns of loss of interpersonal warmth in frontotemporal dementia syndromes are predicted by altered intrinsic network connectivity.NeuroImage. Clinical · 2019Article
- Individual differences in socioemotional sensitivity are an index of salience network function.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
- The Original Social Network: White Matter and Social Cognition.Trends in cognitive sciences · 2018Review
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe aimed to investigate whether cognitive deficits and structural and functional connectivity changes can be detected before symptom onset in a large cohort of carriers of microtubule-associated protein tau and progranulin mutations.
methodsIn this case-control study, 75 healthy individuals (aged 20-70 years) with 50% risk for frontotemporal dementia (FTD) underwent DNA screening, neuropsychological assessment, and structural and functional MRI. We used voxel-based morphometry and tract-based spatial statistics for voxelwise analyses of gray matter volume and diffusion tensor imaging measures. Using resting-state fMRI scans, we assessed whole-brain functional connectivity to frontoinsula, anterior midcingulate cortex (aMCC), and posterior cingulate cortex.
resultsAlthough carriers (n = 37) and noncarriers (n = 38) had similar neuropsychological performance, worse performance on Stroop III, Ekman faces, and Happé cartoons correlated with higher age in carriers, but not controls. Reduced fractional anisotropy and increased radial diffusivity throughout frontotemporal white matter tracts were found in carriers and correlated with higher age. Reductions in functional aMCC connectivity were found in carriers compared with controls, and connectivity between frontoinsula and aMCC seeds and several brain regions significantly decreased with higher age in carriers but not controls. We found no significant differences or age correlations in posterior cingulate cortex connectivity. No differences in regional gray matter volume were found.
conclusionsThis study convincingly demonstrates that alterations in structural and functional connectivity develop before the first symptoms of FTD arise. These findings suggest that diffusion tensor imaging and resting-state fMRI may have the potential to become sensitive biomarkers for early FTD in future clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.