ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2013
Zoledronic acid enhances bone-implant osseointegration more than alendronate and strontium ranelate in ovariectomized rats.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Effects of Systemic or Local Administration of Zoledronate on Implant Osseointegration: A Preclinical Meta-Analysis.BioMed research international · 2019Pooled it
- Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates.Medicina oral, patologia oral y cirugia bucal · 2025Article
- Increased bone mass but delayed mineralization: in vivo and in vitro study for zoledronate in bone regeneration.BMC oral health · 2024Article
- Local application of zoledronate inhibits early bone resorption and promotes bone formation.JBMR plus · 2024Article
- Article
- Zoledronic Acid Implant Coating Results in Local Medullary Bone Growth.Molecular pharmaceutics · 2022Article
- Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy.Bioactive materials · 2021Article
- Alendronate enhances osseointegration in a murine implant model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta.BioMed research international · 2021Article
- Histomorphometric Evaluation of Peri-Implant Bone Response to Intravenous Administration of Zoledronate (ZometaMaterials (Basel, Switzerland) · 2020Article
- Prevention of ovariectomy-induced osteoporosis in rats : Comparative study of zoledronic acid, parathyroid hormone (1-34) and strontium ranelate.Zeitschrift fur Gerontologie und Geriatrie · 2019Article
- Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies.International journal of implant dentistry · 2018Review
- Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats.Clinical oral investigations · 2018Article
- Lithium chloride enhances bone regeneration and implant osseointegration in osteoporotic conditions.Journal of bone and mineral metabolism · 2017Article
- Effect of osteoporosis medications on fracture healing.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Review
- Citrate-based biphasic scaffolds for the repair of large segmental bone defects.Journal of biomedical materials research. Part A · 2015Article
- A Strontium-Modified Titanium Surface Produced by a New Method and Its Biocompatibility In Vitro.PloS one · 2015Article
- Pharmacologic augmentation of implant fixation in osteopenic bone.Current osteoporosis reports · 2014Review
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThis study was designed to compare the effects of alendronate (ALN), strontium ranelate (SR), and zoledronic acid (ZOL) on bone-implant osseointegration in ovariectomized rats. Histological examination and biomechanical tests show that ZOL, ALN, and SR enhance bone-implant osseointegration; ALN and SR have similar effects, while ZOL enhances bone-implant osseointegration more than ALN and SR
introductionThis study aims to compare the effects of ALN, SR, and ZOL on bone-implant osseointegration in ovariectomized rats.
methodsSixty female Sprague-Dawley rats were included in this study. Of them, 48 rats were ovariectomized (OVX) and assigned to four groups: OVX (OVX + Veh), ALN (OVX + ALN), SR (OVX + SR), and ZOL (OVX + ZOL). And another 12 rats were sham-operated as a control group (Sham). Four weeks after ovariectomy, HA-coated titanium implants were inserted into the tibias bilaterally in all rats. Then the rats in groups ALN, SR, and ZOL were systemically administrated with alendronate (7 mg/kg/week, orally), strontium ranelate (500 mg/kg/day, orally), or a single injection of zoledronic acid (0.1 mg/kg, iv), respectively. Twelve weeks after implantation, all rats were sacrificed to get the femurs and tibias. Histological examination and biomechanical tests were used to evaluate bone-implant osseointegration in all groups.
resultsALN, SR, and ZOL significantly increased distal femoral BMD when compared with group OVX; ZOL increased BMD significantly more than ALN and SR (P < 0.05). Significant increase of bone-to-implant contact and peri-implant bone fraction were observed in groups ALN, SR, and ZOL when compared with group OVX (P < 0.05). Groups ALN and SR were inferior to groups ZOL and Sham (P < 0.05) in bone-to-implant contact and peri-implant bone fraction. Similar results were found in biomechanical testing (max pushout force).
conclusionsIn rats losing bone rapidly after ovariectomy, systemic administration of ZOL, ALN, and SR causes better bone-implant osseointegration when compared to OVX; ALN and SR have similar positive effects on osseointegration, while ZOL, that was given in a dose with more positive BMD effect than that of ALN or SR, causes better osseointegration than either ALN or SR.
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