ArticleMolecular biology of the cell2013
Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.
Article in Molecular biology of the cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Polo-like kinase Cdc5 orchestrates Cdk1 regulation via Swe1 and Mih1 during meiotic prophase I exit.Communications biology · 2026Article
- Lipid packing and local geometry influence septin curvature sensing.The Journal of cell biology · 2026Article
- Hog1 activation delays mitotic exit via phosphorylation of Net1.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Haspin Modulates the G2/M Transition Delay in Response to Polarization Failures in Budding Yeast.Frontiers in cell and developmental biology · 2020Article
- Article
- Dynamic regulation of Cdr1 kinase localization and phosphorylation during osmotic stress.The Journal of biological chemistry · 2017Article
- Shrinking Daughters: Rlm1-Dependent GGenetics · 2017Article
- Genome-Wide Screen for Haploinsufficient Cell Size Genes in the Opportunistic YeastG3 (Bethesda, Md.) · 2017Article
- Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.Molecular biology of the cell · 2016Article
- Tunable ultrasensitivity: functional decoupling and biological insights.Scientific reports · 2016Article
- Septin Form and Function at the Cell Cortex.The Journal of biological chemistry · 2015Review
- Molecular mechanism of flocculation self-recognition in yeast and its role in mating and survival.mBio · 2015Article
- Budding yeast Swe1 is involved in the control of mitotic spindle elongation and is regulated by Cdc14 phosphatase during mitosis.The Journal of biological chemistry · 2015Article
- Septins and Generation of Asymmetries in Fungal Cells.Annual review of microbiology · 2015Review
- Systematic identification of cell size regulators in budding yeast.Molecular systems biology · 2014Article
- Fungal pathogens are platforms for discovering novel and conserved septin properties.Current opinion in microbiology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae cells exposed to a variety of physiological stresses transiently delay bud emergence or bud growth. To maintain coordination between bud formation and the cell cycle in such circumstances, the morphogenesis checkpoint delays nuclear division via the mitosis-inhibitory Wee1-family kinase, Swe1p. Swe1p is degraded during G2 in unstressed cells but is stabilized and accumulates following stress. Degradation of Swe1p is preceded by its recruitment to the septin scaffold at the mother-bud neck, mediated by the Swe1p-binding protein Hsl7p. Following osmotic shock or actin depolymerization, Swe1p is stabilized, and previous studies suggested that this was because Hsl7p was no longer recruited to the septin scaffold following stress. However, we now show that Hsl7p is in fact recruited to the septin scaffold in stressed cells. Using a cyclin-dependent kinase (CDK) mutant that is immune to checkpoint-mediated inhibition, we show that Swe1p stabilization following stress is an indirect effect of CDK inhibition. These findings demonstrate the physiological importance of a positive-feedback loop in which Swe1p activity inhibits the CDK, which then ceases to target Swe1p for degradation. They also highlight the difficulty in disentangling direct checkpoint pathways from the effects of positive-feedback loops active at the G2/M transition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.