ArticleArchives of women's mental health2013
Prevalence and trends in the use of antipsychotic medications during pregnancy in the U.S., 2001-2007: a population-based study of 585,615 deliveries.
Article in Archives of women's mental health, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 7 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Systematic Review: Antipsychotic Medication in Pregnancy and Neurodevelopmental Outcomes in Children.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Antipsychotic drug use during pregnancy and neonatal outcomes: a systematic review and meta-analysis.Archives of women's mental health · 2026Pooled it
- Pooled it
- [Antipsychotics during pregnancy: a systematic review].Der Nervenarzt · 2021Pooled it
- Antipsychotic Exposure in Pregnancy and the Risk of Gestational Diabetes: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2020Pooled it
- Obstetric and neonatal outcomes after antipsychotic medication exposure in pregnancy.Obstetrics and gynecology · 2015Pooled it
- Electroconvulsive therapy during pregnancy: a systematic review of case studies.Archives of women's mental health · 2015Pooled it
- Brexpiprazole and Quetiapine Use During Pregnancy and Lactation: A Case Report.Clinical case reports · 2026Article
- Risk of Major Congenital Malformations Associated With the First-Trimester Exposure to Antipsychotics: A Large Claims Database Study.Pharmacology research & perspectives · 2026Article
- Review
- The Developmental Toxicity of Haloperidol on Zebrafish (Biomedicines · 2025Article
- Prescription medication use during pregnancy in the United States from 2011 to 2020: trends and safety evidence.American journal of obstetrics and gynecology · 2024Article
- Pregnancy related complications in women with hypertrophic cardiomyopathy: a nationwide population-based cohort study.BMC cardiovascular disorders · 2024Article
- Inpatient antipsychotic medication switching and rehospitalization risk among patients with schizophrenia-spectrum disorders.Schizophrenia research · 2024Article
- Antipsychotic-induced weight gain: exploring the role of psychiatrists in managing patients' physical health - challenges, current options and direction for future care.BJPsych bulletin · 2024Article
- The Association of Perceived Labor Agentry and Depression and/or Anxiety.American journal of perinatology · 2023Article
- Physiologically-based pharmacokinetic model to investigate the effect of pregnancy on risperidone and paliperidone pharmacokinetics: Application to a pregnant woman and her neonate.Clinical and translational science · 2023Article
- A Review: Integrative Perspectives on the Features and Clinical Management of Psychotic Episodes in Pregnancy.Journal of clinical medicine · 2023Review
- Neurodevelopment in school-aged children after intrauterine exposure to antipsychotics.Acta psychiatrica Scandinavica · 2023Article
- The maternal health of American Indian and Alaska Native people: A scoping review.Social science & medicine (1982) · 2023Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
This study aims to estimate the prevalence of and temporal trends in prenatal antipsychotic medication use within a cohort of pregnant women in the U.S. We identified live born deliveries to women aged 15-45 years in 2001-2007 from 11 U.S. health plans participating in the Medication Exposure in Pregnancy Risk Evaluation Program. We ascertained prenatal exposure to antipsychotics from health plan pharmacy dispensing files, gestational age from linked infant birth certificate files, and ICD-9-CM diagnosis codes from health plan claims files. We calculated the prevalence of prenatal use of atypical and typical antipsychotics according to year of delivery, trimester of pregnancy, and mental health diagnosis. Among 585,615 qualifying deliveries, 4,223 (0.72%) were to women who received an atypical antipsychotic and 548 (0.09%) were to women receiving a typical antipsychotic any time from 60 days before pregnancy through delivery. There was a 2.5-fold increase in atypical antipsychotic use during the study period, from 0.33% (95% confidence interval: 0.29%, 0.37%) in 2001 to 0.82% (0.76%, 0.88%) in 2007, while the use of typical antipsychotics remained stable. Depression was the most common mental health diagnosis among deliveries to women with atypical antipsychotic use (63%), followed by bipolar disorder (43%) and schizophrenia (13%). The number and proportion of pregnancies exposed to atypical antipsychotics has increased dramatically in recent years. Studies are needed to examine the comparative safety and effectiveness of these medications relative to other therapeutic options in pregnancy.
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