Evidence map›Paper›PMID 23389402›Full record

ReviewToxins2013

Studies in mice reveal a role for anthrax toxin receptors in matrix metalloproteinase function and extracellular matrix homeostasis.

Claire Reeves, Pelisa Charles-Horvath, Jan Kitajewski

Open access · goldAbstract readReview
In one paragraph

Review in Toxins, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Beyond FAP: ANTXR1 as a novel target for PET imaging and radio-ligand therapy in immuno-oncology?European journal of nuclear medicine and molecular imaging · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis.Matrix biology : journal of the International Society for Matrix Biology · 2015
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Claire ReevesDepartment of Ob/Gyn, Columbia University Medical Center, New York, NY 10032, USA. creeves2002@gmail.com
Pelisa Charles-Horvath
Jan Kitajewski
Columbia University Irving Medical Center · US

Funding

Hormones: Molecular Mechanism of Action and FunctionsT32DK007328 · NIDDK · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KOUSTENI, STAVROULA · 1986 to 2025
$7.8M
CELL, MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CANCERT32CA009503 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAUTIER, JEAN · 1985 to 2016
$6.8M
Role of Anthrax Toxin Receptors in Angiogenesis and EndotheliumR01AI064654 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KITAJEWSKI, JAN K. · 2008 to 2012
$2.0M
NCI NIH HHS 5T32 CA009503-24NCI NIH HHS T32 CA009503NIAID NIH HHS R01 AI064654NIDDK NIH HHS T32 DK007328
6 · The paper itself

Abstract

The genes encoding Anthrax Toxin Receptors (ANTXRs) were originally identified based on expression in endothelial cells suggesting a role in angiogenesis. The focus of this review is to discuss what has been learned about the physiological roles of these receptors through evaluation of the Antxr knockout mouse phenotypes. Mice mutant in Antxr genes have defects in extracellular matrix homeostasis. We discuss how knowledge of physiological ANTXR function relates to what is already known about anthrax intoxication.

Indexed as

AnimalsAntigens, BacterialBacterial ToxinsExtracellular MatrixHomeostasisHumansMatrix MetalloproteinasesMiceNeoplasmsReceptors, PeptideReproductionanthrax toxinanthrax toxin receptorsAntigens, BacterialBacterial ToxinsMatrix MetalloproteinasesReceptors, Peptide

Identifiers

PMID23389402
PMCPMC3640537
OpenAlexW2044294923

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.