ArticleWorld journal of pediatrics : WJP2013
Effect of proton pump inhibition on acid, weakly acid and weakly alkaline gastro-esophageal reflux in children.
Article in World journal of pediatrics : WJP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- Balancing therapeutic benefits and hidden risks of proton pump inhibitors in pediatric practice: a narrative review and update.Clinical and experimental pediatrics · 2026Article
- Characteristics of esophageal refluxate and symptoms in infants compared between pre-treatment and on treatment with proton pump inhibitors.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Efficacy and Safety of Domperidone in Combination with Proton Pump Inhibitors in Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Journal of clinical medicine · 2022Review
- Understanding Cystic Fibrosis Comorbidities and Their Impact on Nutritional Management.Nutrients · 2022Review
- Prescription of acid inhibitors in infants: an addiction hard to break.European journal of pediatrics · 2020Article
- Article
- Management of gastroesophageal reflux disease in pediatric patients with cerebral palsy.Canadian family physician Medecin de famille canadien · 2019Article
- The Gastroesophageal Reflux Disease Questionnaire in Adolescents: What Is the Best Cutoff Score?Pediatric gastroenterology, hepatology & nutrition · 2019Article
- Evaluation and Treatment of Malnutrition and Associated Gastrointestinal Complications in Children with Cerebral Palsy.Pediatric gastroenterology, hepatology & nutrition · 2019Review
- Temporal Association Between Reflux-like Behaviors and Gastroesophageal Reflux in Preterm and Term Infants.Journal of pediatric gastroenterology and nutrition · 2016Article
- Clinical value of wireless pH-monitoring of gastro-esophageal reflux in children before and after proton pump inhibitors.BMC gastroenterology · 2014Article
- Comparative safety and efficacy of proton pump inhibitors in paediatric gastroesophageal reflux disease.Drug safety · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effect of proton pump inhibitors on the characteristics of gastroesophageal reflux (GER) in children and adolescents was evaluated.
methodsTwenty-one children and adolescents with symptoms suggesting GER disease (GERD) underwent upper endoscopy and a 24-hour multichannel intraluminal impedance/pH (MII-pH) monitoring before and at the end of 2 months of therapy with proton pump inhibitors (PPIs).
resultsFourteen (67%) patients reported clinically relevant symptom improvement after 2 months of PPIs intake. At the first endoscopy, 8 (38%) patients had macroscopic signs of reflux esophagitis; after two months of therapy, 6/8 (75%) patients had a complete mucosal recovery. There was a significant reduction in the total percentage of mean acid reflux time (from 13.1% to 3.8%), and the De Meester score dropped to normal (from 46.4 to 13.1). The mean number of acid refluxes decreased significantly from 48 to 15 per 24 hours, while inversely, the mean number of weakly acid refluxes increased significantly from 26 to 64 per 24 hours. PPI therapy did not affect the total number of reflux episodes, the number of liquid and mixed refluxes, the duration of esophageal bolus exposure and proximal extent of the reflux.
conclusionsIn children and adolescents with GERD, PPIs do not affect the total number of reflux episodes. PPIs only decrease the acidity of refluxate. Nevertheless, the majority of patients with typical reflux symptoms may report symptom improvement. Esophagitis can be healed after PPI treatment. The treatment of weakly acid and weakly alkaline reflux remains a challenge for physicians in the future.
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