ArticleCarcinogenesis2013
Hemochromatosis (HFE) gene mutations and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
Article in Carcinogenesis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The risk of new-onset cancer associated with HFE C282Y and H63D mutations: evidence from 87,028 participants.Journal of cellular and molecular medicine · 2016Pooled it
- Gene-diet interactions in gastric cancer risk: a systematic review.World journal of gastroenterology · 2014Pooled it
- C282Y polymorphism in the HFE gene is associated with risk of breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Article
- Gastric Adenocarcinoma With Enteroblastic Differentiation Presenting as Lung Nodules: A Diagnostic Dilemma.Journal of community hospital internal medicine perspectives · 2025Article
- Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia.Vox sanguinis · 2024Article
- Article
- Iron Metabolism in Cancer Progression.International journal of molecular sciences · 2020Review
- The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system.Immunity, inflammation and disease · 2017Review
- Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.Oncotarget · 2017Article
- Beyond Human Leukocyte Antigen Class I Antigens: Hereditary Hemochromatosis Gene Mutations in Recurrent Aphthous Oral Ulcers and Behçet Disease in the South of Tunisia.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Body iron status and gastric cancer risk in the EURGAST study.International journal of cancer · 2015Article
- Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks.Cancers · 2015Article
- Association of the apolipoprotein E 2 allele with concurrent occurrence of endometrial hyperplasia and endometrial carcinoma.Oxidative medicine and cellular longevity · 2015Article
- Screening of susceptibility genes and multi-gene risk analysis in gastric cancer.Medical oncology (Northwood, London, England) · 2014Article
- Evidence for the Influence of the Iron Regulatory MHC Class I Molecule HFE on Tumor Progression in Experimental Models and Clinical Populations.Translational oncogenomics · 2014Review
- Iron and thiols as two major players in carcinogenesis: friends or foes?Frontiers in pharmacology · 2014Review
- Toenail iron, genetic determinants of iron status, and the risk of glioma.Cancer causes & control : CCC · 2013Article
Corrections and comments
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Authors and funding
43 authors at 20 institutions in 11 countries.
Funding
Abstract
Hereditary hemochromatosis (HH) is a strong risk factor for hepatocellular cancer, and mutations in the HFE gene associated with HH and iron overload may be related to other tumors, but no studies have been reported for gastric cancer (GC). A nested case-control study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), including 365 incident gastric adenocarcinoma and 1284 controls matched by center, sex, age and date of blood collection. Genotype analysis was performed for two functional polymorphisms (C282Y/rs1800562 and H63D/rs1799945) and seven tagSNPs of the HFE genomic region. Association with all gastric adenocarcinoma, and according to anatomical localization and histological subtype, was assessed by means of the odds ratio (OR) and 95% confidence interval (CI) estimated by unconditional logistic regression adjusted for the matching variables. We observed a significant association for H63D with OR (per rare allele) of 1.32 (CI = 1.03-1.69). In subgroup analyses, the association was stronger for non-cardia anatomical subsite (OR = 1.60, CI = 1.16-2.21) and intestinal histological subtype (OR = 1.82, CI = 1.27-2.62). Among intestinal cases, two tagSNPs (rs1572982 and rs6918586) also showed a significant association that disappeared after adjustment for H63D. No association with tumors located in the cardia or with diffuse subtype was found for any of the nine SNPs analyzed. Our results suggest that H63D variant in HFE gene seems to be associated with GC risk of the non-cardia region and intestinal type, possibly due to its association with iron overload although a role for other mechanisms cannot be entirely ruled out.
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Registered trials
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