ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Regional relation between skin blood flow and sweating to passive heating and local administration of acetylcholine in young, healthy humans.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- At what level of heat load are age-related impairments in the ability to dissipate heat evident in females?PloS one · 2015Trial
- Quantifying microvascular responses to local heating using optical coherence tomography: Comparison between skin sites and sex differences.Experimental physiology · 2025Article
- Effect of reflex and mechanical decreases in skin perfusion on thermal- and agonist-induced eccrine sweating in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Body mapping of regional sweat distribution in young and older males.European journal of applied physiology · 2021Article
- Historical reviews of the assessment of human cardiovascular function: interrogation and understanding of the control of skin blood flow.European journal of applied physiology · 2020Review
- The Dynamic and Correlation of Skin Temperature and Cardiorespiratory Fitness in Male Endurance Runners.International journal of environmental research and public health · 2019Article
- Self-Reported Everyday Psychosocial Stressors Are Associated With Greater Impairments in Endothelial Function in Young Adults With Major Depressive Disorder.Journal of the American Heart Association · 2019Article
- Oxidative Stress Contributes to Microvascular Endothelial Dysfunction in Men and Women With Major Depressive Disorder.Circulation research · 2019Article
- Skin microdialysis: methods, applications and future opportunities-an EAACI position paper.Clinical and translational allergy · 2019Review
- The effect of hot and cold drinks on thermoregulation, perception, and performance: the role of the gut in thermoreception.European journal of applied physiology · 2018Article
- Sustained increases in skin blood flow are not a prerequisite to initiate sweating during passive heat exposure.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- The colours of humanity: the evolution of pigmentation in the human lineage.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- The biophysical and physiological basis for mitigated elevations in heart rate with electric fan use in extreme heat and humidity.International journal of biometeorology · 2017Article
- Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Effects of increased skin blood flow on muscle oxygenation/deoxygenation: comparison of time-resolved and continuous-wave near-infrared spectroscopy signals.European journal of applied physiology · 2015Article
- Aging impairs heat loss, but when does it matter?Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Nonuniform, age-related decrements in regional sweating and skin blood flow.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
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3 authors.
Funding
Abstract
Regional variation in sweating over the human body is widely recognized yet variation in vasomotor responses and mechanisms causing this variation remain unclear. This study aimed to explore the relation between regional sweating rates (RSR) and skin blood flow (SkBF) responses to thermal and pharmacological stimuli in young, healthy subjects. In nine subjects (23 ± 3 yr), intradermal microdialysis (MD) probes were inserted into the ventral forearm, abdomen, thigh, and lower back and perfused with lactated Ringer solution. RSR over each MD membrane were measured using ventilated capsules with a laser Doppler probe housed in each capsule for measurement of red cell flux (laser Doppler flux, LDF) as an index of SkBF. Subjects completed a whole body heating protocol to 1°C rise in oral temperature and an acetylcholine dose response (ACh 1 × 10(-7)-0.1 M; mean skin temperature 34°C). Maximal LDF were obtained at the end of both protocols (50 mM sodium nitroprusside).During heating RSR varied among sites (P < 0.0001) and was greater on the back versus other sites (P < 0.05), but LDF was similar between sites (P = 0.343). RSR and SkBF showed a strong relation during initial (arm: r = 0.77 ± 0.09, thigh: r = 0.81 ± 0.08, abdomen: r = 0.89 ± 0.04, back: r = 0.86 ± 0.04) but not latter stages of heating. No differences in RSR (P = 0.160) or SkBF (LDF, P = 0.841) were observed between sites during ACh perfusion. Taken together, these data suggest that increases in SkBF are necessary to initiate and increase sweating, but further rises in RSR are not fully dependent on SkBF in a dose-response manner. Furthermore, RSR cannot be explained by cholinergic sensitivity or variation in SkBF.
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