ArticleMarine drugs2013
Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- Protective Effects ofJournal of microbiology and biotechnology · 2024Article
- Antioxidant Activity and Inhibition of Liver Cancer Cells' Growth of Extracts from 14 Marine Macroalgae Species of the Mediterranean Sea.Foods (Basel, Switzerland) · 2023Article
- Pro-Apoptotic Activity of Bioactive Compounds from Seaweeds: Promising Sources for Developing Novel Anticancer Drugs.Marine drugs · 2023Review
- Cytotoxic Potential of the Marine DiatomMarine drugs · 2022Article
- A concise review of the bioactivity and pharmacological properties of the genusJournal of applied phycology · 2022Review
- The Use of Invasive Algae Species as a Source of Secondary Metabolites and Biological Activities: Spain as Case-Study.Marine drugs · 2021Review
- Chinese Medicine for Psoriasis Vulgaris Based on Syndrome Pattern: A Network Pharmacological Study.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Chemical Diversity ofMolecules (Basel, Switzerland) · 2019Article
- New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds.Marine drugs · 2019Review
- From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds.Frontiers in pharmacology · 2018Review
- Bioactive Potential of Marine Macroalgae from the Central Red Sea (Saudi Arabia) Assessed by High-Throughput Imaging-Based Phenotypic Profiling.Marine drugs · 2017Article
- High cytotoxicity and anti-proliferative activity of algae extracts on an in vitro model of human hepatocellular carcinoma.SpringerPlus · 2016Article
- New α-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs.Marine drugs · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cytotoxic effects and mechanism of action of clerosterol, isolated from the marine alga Codium fragile, were investigated in A2058 human melanoma cells. Clerosterol inhibited the growth of A2058 cells with an IC(50) of 150 µM and induced apoptotic cell death, as evidenced by DNA fragmentation, an increase in the number of sub-G(1) hypodiploid cells and the presence of apoptotic bodies. Clerosterol treatment caused the loss of mitochondrial membrane potential. Alterations in the expression of apoptosis-associated proteins in response to clerosterol treatment included upregulation of Bax, downregulation of Bcl-2 and activation of caspases 3 and 9. The pan-caspase inhibitor treatment attenuated the expression of the active form of caspases and cell death induced by clerosterol. The present results show that clerosterol exerts its cytotoxic effect in A2058 human melanoma cells by caspases-dependent apoptosis.
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